This study found that type XVII collagen (COL17) regulates interfollicular epidermis proliferation in both neonatal and aged mice through Wnt signaling, suggesting its potential as a target for anti-aging skin strategies.
June 2015 in “Biomedical and biopharmaceutical research” This article reviews EU cosmetic product claim regulations and highlights increased harmonization and enforcement while reporting no new results.
September 2014 in “Aktuelle Dermatologie” This symposium review highlights past, present, and future developments in skin research, celebrating the work of Prof. Johanna Brandner and Dr. Peter Arne Gerber, without reporting new clinical results.
March 2014 in “Institutional Repositories DataBase (IRDB)” Skin-derived stem cells could help treat skin aging and pigmentation issues.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
May 2013 in “Springer eBooks” Skin problems in the elderly are unique and may indicate other diseases, involving changes in skin, hair, nails, and increased cancer risk.
January 2012 in “Journal of Investigative Dermatology” The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
October 2020 in “Reactions Weekly” Finasteride can cause multiple side effects like tremors, dry skin, and rapid aging.
July 2023 in “International Journal of Cosmetic Science” This article reviews how biopolymers are utilized in cosmetics, highlighting their biodegradable and non-toxic properties, recent structural developments, novel applications, and safety considerations in the formulation of skin, hair, and oral care products.
June 2010 in “Journal of Cosmetic Dermatology” This article reviews the concept of caloric restriction and its potential anti-aging effects, highlighting animal studies and a human experiment in Biosphere II, but notes significant challenges for its application in humans.
January 2026 in “Frontiers in Cellular Neuroscience” This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.
October 2018 in “Oncology Times” This commentary discusses the cultural and biological significance of hair, intertwined with humorous and poignant anecdotes from cancer care, and reports no new research findings.
105 citations
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January 2010 in “Mediators of Inflammation” This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.
12 citations
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August 2022 in “Stem cell reviews and reports” This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by interacting with SIRT1 and PARP1, highlighting a potential mechanism for addressing aging-related diseases.
8 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” Skin health and diseases are closely linked to metabolic processes.
1 citations
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June 2023 in “Pharmacognosy Research” This review highlights the promising therapeutic potential of Bacopa monnieri in treating various health conditions, particularly related to neuropharmacology, but emphasizes the need for further clinical research.
December 2024 in “International Journal Of Ayurvedic And Herbal Medicine” This review highlights Shirodhara's potential cosmetic benefits, noting improvements in scalp health, hair growth, and skin appearance, attributed to stress reduction, hormonal balance, enhanced circulation, and nutrient-rich herbal oils.
14 citations
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July 2011 in “Clinics in plastic surgery” This review discusses the use of dermabrasion as an effective skin resurfacing technique for treating aging effects and reports no new clinical results.
1 citations
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January 2009 in “Elsevier eBooks” This chapter provides an overview of skin physiology, aging effects, and how environmental factors like UV damage impact skin health, without presenting new research findings.
35 citations
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January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” This study found that deleting the CD98hc protein in mouse skin impairs wound healing and homeostasis, resembling aging effects, due to disrupted integrin signaling pathways.
In this study on mice, researchers developed CLA-loaded nanovesicles that showed potential anti-aging effects on hair follicles and enhanced hair growth compared to commercial minoxidil, with lower skin irritation, suggesting a promising approach for treating androgenetic alopecia.
Skin changes throughout life, from development before birth to aging effects like wrinkles, influenced by both genetics and environment.
2 citations
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June 2023 in “Journal of clinical medicine” This review found that both oral and topical soy-based products showed positive effects on various skin-related outcomes, including aging signs and skin barrier function, but topical applications were more likely to improve skin barrier status compared to oral supplementation.
1 citations
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November 2021 in “IntechOpen eBooks” This review covers red light Transcranial LED therapy for hippocampal memory impairment in aging and Alzheimer's but reports no clinical results, highlighting a need for further research into its mechanisms and effects.
1 citations
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January 2019 in “Journal of Embryology & Stem Cell Research” This review discusses mesenchymal stem cells' role in tissue regeneration and skin anti-aging, highlighting their migration to damaged sites and secretome effects, but reports no new clinical results.
1 citations
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November 2008 in “Gerontology” This article discusses the increasing use of lifestyle drugs by healthy individuals to alter appearance or slow aging and emphasizes the need for doctors to consider side effects and contraindications, but it reports no new clinical findings.
June 2026 in “Preprints.org” This study found that in healthy young men, oral minoxidil at 5 mg/day led to increased carotid intima-media thickness and vascular aging, suggesting potential cardiovascular side effects at higher doses. A dose-dependent effect was observed, while dutasteride displayed a favorable vascular profile without significant changes.
November 2023 in “Global journal of medical research” This study highlights the importance of understanding the rheological properties of hyaluronic acid fillers, including viscosity, cross-linking, and concentration, to optimize their use in addressing facial aging by maximizing clinical effects.
65 citations
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September 2014 in “Orphanet Journal of Rare Diseases” This study identified mutations in the STUB1 gene linked to hereditary cerebellar ataxia with cognitive impairment, revealing potential effects on protein function and patient symptoms, including accelerated aging.
This source highlights Amla's potential as a natural remedy due to its high vitamin C, fiber, iron, and antioxidant content, marking its benefits in slowing aging, enhancing hair and skin health, managing diabetes, and exhibiting anticancer, antioxidant, and immunomodulatory effects.