Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor-β (TGF-β)/Mesenchymal Stem Cells (MSCs) Balance: A Complex Partnership in Skin Rejuvenation
January 2019
in “
Journal of Embryology & Stem Cell Research
”
mesenchymal stem cells MSCs skin rejuvenation tissue regeneration vascular endothelial growth factor VEGF Transforming Growth Factor-β TGF-β Growth Differentiation Factor 11 GDF11 inflammatory responses cytokines extracellular vesicles dermal fibroblasts keratinocytes adipose-derived stem cells ADSCs stem cells growth factors skin cells inflammation fat-derived stem cells
TLDR MSCs help rejuvenate skin by promoting cell growth and reducing inflammation.
The document discussed the role of mesenchymal stem cells (MSCs) in skin rejuvenation and tissue regeneration, highlighting their ability to migrate to damaged sites and differentiate into various skin cell components. MSCs were shown to secrete key proteins like vascular endothelial growth factor (VEGF), Transforming Growth Factor-β (TGF-β), and Growth Differentiation Factor 11 (GDF11), which are crucial for tissue regeneration. The study noted that MSCs could help coordinate inflammatory responses and inhibit harmful cytokines, although the exact mechanisms of tissue degeneration and cell aging remained unclear. The secretome of MSCs, particularly extracellular vesicles, was identified as significant in promoting the migration and proliferation of dermal fibroblasts and keratinocytes, with GDF11 and TGF-β playing central roles. Additionally, adipose-derived stem cells (ADSCs) were mentioned as a newer, less invasive source of adult stem cells.
