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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

Genetics and hormones cause hair loss; finasteride treats it safely.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

ARL15 is important for fat cell development and the release of the hormone adiponectin.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Looking at skin can help find and treat serious diseases early.

The document concludes that various drugs can manage symptoms and metabolic issues in women with PCOS.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Most hirsutism patients had idiopathic hirsutism or PCOS, with hormonal imbalances and signs like acne and irregular periods.

Testosterone helps human pancreatic cells increase insulin release.

Menopause can cause skin issues, and seeing a dermatologist helps.