106 citations,
January 2013 in “Clinical and Developmental Immunology” Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.
102 citations,
July 2020 in “International journal of molecular sciences” Hormones like testosterone and estrogen significantly affect hair growth and structure.
99 citations,
January 2004 in “Journal of Biological Chemistry” Methylprednisolone helps skin cells stick together better in pemphigus vulgaris.
90 citations,
May 2019 in “Drugs” Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.
61 citations,
September 2010 in “Journal of Dermatological Science” Stress hormones and autoimmune reactions can cause hair loss.
58 citations,
March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv” Hormones and signaling pathways control sebaceous gland function and could help treat acne.
52 citations,
May 1997 in “Journal of Biological Chemistry” High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.
51 citations,
December 2017 in “Skin Appendage Disorders” Stress may trigger hair loss by affecting immune protection in hair follicles.
44 citations,
November 2018 in “Journal of applied ecology” Hair analysis for stress and reproductive hormones in wildlife needs more research for accuracy across species.
43 citations,
May 1999 in “Journal of Biological Chemistry” Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.
32 citations,
January 2017 in “Physiology & Behavior” New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.
29 citations,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
26 citations,
February 2022 in “Journal of pineal research” Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.
26 citations,
July 2012 in “Journal of family planning and reproductive health care” The document says that hirsutism in women usually needs hair removal and hormone treatment to manage symptoms and improve well-being.
24 citations,
April 2013 in “PLOS ONE” TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.
20 citations,
March 2022 in “Journal of clinical medicine” Nearly half of the studied men with long COVID had low testosterone, including younger men.
18 citations,
March 2015 in “Journal of Investigative Dermatology” Silencing certain circadian clock genes increases skin pigmentation.
16 citations,
January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
16 citations,
January 2021 in “Frontiers in veterinary science” Pigs in farrowing crates and loose-housing systems showed no difference in chronic stress levels as measured by hair cortisol.
16 citations,
January 2014 in “Obesity surgery” Vertical sleeve gastrectomy improved metabolism, behavior, and reproduction in obese rats with PCOS.
15 citations,
January 2020 in “Experimental Dermatology” The document concludes that understanding and treatments for alopecia areata have significantly advanced, now recognizing it as an autoimmune disorder.
15 citations,
December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health” EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.
14 citations,
April 2022 in “Climacteric” Menopause causes dry skin, wrinkles, and hair changes, with hormone therapy helping but not recommended just for these issues.
14 citations,
March 2022 in “Clinical Endocrinology” The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).
14 citations,
May 2017 in “InTech eBooks” Hair is important for protection, social interaction, and temperature control, and is made of a growth cycle-influenced follicle and a complex shaft.
12 citations,
January 2018 in “Journal of Clinical Laboratory Analysis” Certain IL-18 gene variations may increase the risk of alopecia areata.
11 citations,
October 2020 in “General and comparative endocrinology” Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.
11 citations,
April 2020 in “Animals” Moving horses to new places can increase their stress levels, as shown by higher stress hormone in their hair.
10 citations,
July 2022 in “Dermatology and Therapy” Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.
10 citations,
October 2012 in “Andrology” Prostate cancer can progress even with low testosterone due to internal hormone production in the tumor.