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Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.

Altering SSAT affects fat metabolism and body fat in mice.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

ACBP is crucial for healthy skin in mice.

The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.

A gene called Gk5 controls lipid production in the skin and affects hair growth.

Biotin supplements are unnecessary for most people but may help with certain conditions like biotin deficiency, brittle nails, and some hair loss.

Biotin is important for health, but taking extra usually doesn't help unless you're deficient.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

An imbalanced gut and lack of biotin can cause hair loss in mice.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

SHBG may be a useful early indicator and treatment target for PCOS.

Quercetin may help with PCOS symptoms, but more research is needed.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Systemic diseases can cause hair loss, which is often reversible with treatment.

Human body's immune cells are more common in the layer of fat just beneath the skin than in deeper fat layers.

Apple polyphenols, especially from unripe apples, can help prevent cells from turning into fat cells.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

ADT-G may be a useful indicator of increased androgen levels in women with acne and can be lowered with certain birth control pills.

Breast cancer may be detectable through changes in scalp hair lipids.

Metformin helps reduce PCOS-related infertility by improving insulin sensitivity and inducing ovulation.