TLDR Metformin helps reduce PCOS-related infertility by improving insulin sensitivity and inducing ovulation.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by anovulation, hyperandrogenism, and insulin resistance (IR). This review highlights that metformin, a medication used to treat PCOS, significantly reduces serum androgen levels, improves insulin sensitivity, restores menstrual cycles, and induces ovulation, thereby addressing PCOS-related infertility. The review also aims to elucidate the prevalence of PCOS, particularly in Saudi Arabia, its pathogenesis, and the overall impact on patient health, while detailing metformin's mechanism of action and therapeutic benefits.
Cited in this study
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883 citations
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August 2016 in “Nature Reviews Disease Primers” Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.
222 citations
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January 2014 in “International journal of reproductive medicine” Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.
69 citations
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March 2011 in “Middle East Fertility Society Journal” PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.
232 citations
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February 2006 in “Andrology” PCOS is caused by both genetics and environmental factors like diet and obesity.
4809 citations
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
4025 citations
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January 2004 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
1 citations
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August 2023 in “Curēus” Metformin helps reduce PCOS-related infertility by improving insulin sensitivity and inducing ovulation.
