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In this study, researchers explored ubiquitination patterns in healthy human skin and CYLD cutaneous syndrome tumors, identifying extensive ubiquitin sites and differential protein ubiquitination linked to tumor pathology, highlighting the role of ubiquitination in tissue architecture and disease mechanisms.

This study describes a protocol for generating a fully functional 3D integumentary organ system from murine induced pluripotent stem cells, including the formation of hair follicles and sebaceous glands that function in vivo.

This study demonstrated that the IVL-DrugFluidic® platform is effective for mass-producing finasteride-loaded polymeric microspheres for long-acting injectables, maintaining stable drug release without an initial burst for a month.

This case report highlights the association of three CX26 gene mutations, particularly the D50N mutation, with keratitis–ichthyosis–deafness syndrome and its potential role in scalp squamous cell carcinoma and breast cancer development in a patient.

This study found that the subtilisin protease Sub3 from Microsporum canis is essential for adherence to the feline epidermis but is not necessary for invading epidermal structures.

This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.

This article describes a new subcision technique intended to simplify the procedure for surgeons without reporting clinical results or outcomes.

Microfluidic models improve testing for aging, wound healing, and oral tissue, reducing animal testing.

This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

This review discusses the role of Ysc84/SH3yl1 proteins in linking actin regulation to membrane morphology changes but reports no new experimental results.

The demineralized bone matrix scaffold is better for cell attachment than the mineralized bone allograft.

This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.

This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.

This study found that extracellular vesicles derived from 3D cultures of cervical cancer cells have small RNA profiles more similar to those in patient plasma than those from 2D cultures.

This case report describes a rare occurrence of ectodermal dysplasia features in a 14-year-old with MBTPS1 gene variants, expanding the known spectrum of related disorders.

This study reports the crystal structure of C28H32O5, revealing its monoclinic symmetry, unit-cell dimensions, and molecular conformation.

This study demonstrated that the Epidermal Biopotential Sensing System (EBSS) can measure digital biomarkers of pain in mice, suggesting potential applications in assessing pain and screening analgesics in populations with communication difficulties.

This study introduced a novel 3D co-culture system that effectively mimics in vivo extracellular matrix dynamics, supporting hair follicle biology research and providing a robust platform for evaluating hair loss treatments through enhanced epithelial-mesenchymal interactions.

This study identified interactions between EGF signaling and the GLI proteins in basal cell carcinoma that may contribute to the limited metastasis seen in this skin cancer.

Understanding tissue self-organization can improve treatments for diseases and advance regenerative medicine.

This study found that ablation of Tet2/Tet3 genes in skin epithelial cells altered hair shape and length, leading to hair loss, by affecting chromatin accessibility and gene expression related to hair follicle regulation.

This study found that manipulating Wnt/β-catenin signaling in embryonic mammary glands impacted their development, with high activity levels hindering branching and potentially redirecting cells toward hair follicle identity instead of mammary tissue.

This study found that in early retinal neurogenesis in mice, the transcription factor Lhx2 regulates Sonic Hedgehog signaling by controlling expression of pathway genes like the co-receptors Gas1 and Cdon.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This study found that photobiomodulation via LED light at 630 nm and 810 nm increased proliferation and mineralization in osteoblast-like cells, with comparable effects between the two wavelengths.

This review evaluates recent advances from 2016 to 2022 in the use of microbubbles and nanobubbles, highlighting their potential for safer diagnostic and therapeutic applications in radiology and medicine without the side effects associated with traditional methods.