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research Primary Cutaneous Rhabdoid Squamous Cell Carcinoma: A Case Report and Review of Molecular Features
This case report describes a rare aggressive variant of squamous cell carcinoma on the scalp of a non-immunosuppressed older male, highlighting its high biological risk for metastasis and poor outcomes.
research 198 Reliable and interpretable segmentation for remote assessment of atopic dermatitis severity using digital images
This study reports that improvements to the EczemaNet pipeline, incorporating pixel-level segmentation and data augmentation, enhanced the reliability and interpretability of assessing atopic dermatitis severity from digital images.
research Microtechnology-based methods for organoid models
This review discusses recent advances in microfabrication and microfluidic technologies for improving the production of organoids and spheroids, but it reports no new experimental results.
research Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Platycladi cacumen by Ultra-performance Liquid Chromatography Coupled with Hierarchical Cluster Analysis
This study established a rapid and accurate ultra-performance liquid chromatographic method for chemical fingerprinting and analyzing Platycladi cacumen, effectively distinguishing batches based on geographical and climatic conditions.
research De novo variation in ARID1B gene causes Coffin-Siris syndrome 1 in a Chinese family with excessive early-onset high myopia
This study is the first to identify a de novo heterozygous frameshift insertion variant in the ARID1B gene as a cause of Coffin-Siris syndrome with an association to excessive early-onset high myopia.
research Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
research A novel method for visualizing hair lipids at the cell membrane complex: Argon sputter etching/scanning electron microscopy1
This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cell membrane complex as distinctive convex structures, shedding light on their role and localization in human hair.
research Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma
This review discusses the mechanism and side effects of smoothened inhibitors for advanced basal cell carcinoma, reporting no new clinical results and highlighting current management strategies for these adverse events.
research Two parietal cephaloceles in a female neonate
This case study reported a successful surgical excision of two cephalocele lesions in a female neonate, resulting in uneventful recovery and appropriate neurodevelopment during a seven-month follow-up.
research 603 Pathological modeling of epidermolysis bullosa simplex (EBS) using induced pluripotent stem cells (iPSC)
This study found that using human induced pluripotent stem cells (iPSC) carrying the causal mutation of Epidermolysis Bullosa simplex provides a robust model for understanding its molecular mechanisms and testing potential therapeutic targets.
research Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases
This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.
research Engineered building bloks to print endogenous tissue and complex organs in vitro
This study introduces a new type of tissue micromodule, the micro tissue precursor (μTP), which can form complex 3D tissues, including lung stroma and skin models supporting hair viability.
research RGB video microscopic system for in-vitro monitoring of optical properties of hair shaft and follicle
This paper presents an RGB video microscopic system to monitor optical properties of hair shafts and follicles in vitro, but reports no new clinical results.
research 301 The Spectrum of PLEC Sequence Variants and Related Plectinopathies Including Novel Association with Epidermolysis Bullosa Pruriginosa
This study identified 15 Iranian patients with PLEC variants linked to various plectinopathies and highlighted a novel association between a homozygous nonsense variant in PLEC and a rare combination of disorders including EB pruriginosa, muscular dystrophy, and congenital myasthenic syndrome.
research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors (SKP) by Microarray Analysis
The study characterized the transcriptional changes in porcine SKP cells transitioning to fibroblast-like cells, indicating potential roles for specific signaling pathways in this cell fate transition.
research Bilateral Xen is Used as Minimally Invasive Glaucoma Surgery for Glaucoma in GAPO Syndrome: Case Report
In this case report, a 36-year-old woman with GAPO syndrome underwent successful XEN gelatin micro-stent implantation in both eyes to control primary open-angle glaucoma that was unresponsive to medical treatment, marking the first documented use of this minimally invasive glaucoma surgery in such a patient.
research New fluorogenic probes for neutral and alkaline ceramidases
This study reports new fluorogenic ceramidase substrates and highlights RBM14C24:1 as an efficient substrate for neutral ceramidase, while RBM15C18:1 is the best probe for measuring ACER1 and ACER2 activities, potentially aiding high-throughput screening for ceramidase inhibitors.
research Hydrogel Lego based on rehydrated laminate assembly for standardized production and customized integration of multifunctional hydrogel sensors
This study introduced a rapid rehydration approach for creating customizable, multifunctional hydrogel sensors, enabling precise detection of surface deformations and easy integration of layers, highlighting its potential for standardized and adaptable manufacturing of wearable devices.
research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity
In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.
research Comparison of Quantitative Evaluation and Conventional Scar Scale Analysis for Pediatric Pathological Scars
This study found that the Antera 3D® system provided an objective and sensitive method for assessing pediatric pathological scars, capturing significant changes in pigmentation, vascularity, and volume, compared to the traditional Vancouver Scar Scale and dermoscopy, which showed varied sensitivities across different scar parameters.
research Investigating the internal structure of sheep wool hair fibre using new microscopic techniques
This research explores the use of serial block-face scanning electron microscopy to model the complex architecture of sheep wool fibres, focusing on the role and distribution of para- and ortho-cortical cells in determining wool curliness, though the mechanism remains unclear.
research Follicular Unit Plain Speak
This abstract introduces the concept of follicular units (FUs) in the human scalp but presents no new research findings.
research Trichoscopy and LC-OCT findings in sonidegib-induced alopecia in patients with advanced basal cell carcinoma
In this study, 45 patients with advanced basal cell carcinoma treated with the medication sonidegib experienced a 24% incidence of alopecia, with detailed trichoscopic and LC-OCT examination revealing specific hair changes, suggesting LC-OCT might help identify early signs of alopecia from sonidegib use.
research Newly emerging type B insulin resistance (TBIR) during treatment with eculizumab for AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD): fatal outcome
This study reports a case of a patient with neuromyelitis optica spectrum disorders treated with eculizumab who developed fatal sepsis after insulin resistance emerged.
research Bioengineering a humanized acne microenvironment model: Proteomics analysis of host responses to Propionibacterium acnes infection in vivo
This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.
research AB0163 ANTI-KU ANTIBODIES: MUCH MORE THAN SCLEROMYOSITIS
This observational study concluded that anti-Ku antibodies do not specifically indicate any systemic autoimmune disease or associated clinical phenotype.
research SnapshotDx Quiz: May 2020
This study reported that specific inhibition of the classical complement pathway with BIVV009 prevented C3 deposition along the dermal-epidermal junction in bullous pemphigoid, reflecting its potential efficacy.
research A Novel Crosslinking Approach for Biomanufacturing of a Collagen‐Based Skin Dermal Template
This study reports that a novel UV-based crosslinking process for collagen sponges significantly decreases crosslinking time compared to traditional methods, and supports effective cell proliferation and wound regeneration in a mouse model, without causing abnormal angiogenic or immune responses.