Engineered Building Blocks to Print Endogenous Tissue and Complex Organs In Vitro

The study explored the development of micro tissue precursors (μTP) as a new class of bio-ink for 3D organ printing, demonstrating their ability to form completely endogenous tissues with complex shapes. The research highlighted the μTP's influence on tissue morphology, ECM maturation, and mechanical properties, as well as their application in a microfluidic platform to study tissue development under various conditions. The study also investigated the creation of lung stroma using bronchial fibroblasts, which supported the differentiation of bronchial epithelial cells into a complete airway epithelium. Additionally, the research evaluated a human skin model's ability to maintain exogenous hair viability, showing promise for future hair follicle structure modeling.