May 2023 in “Research Square (Research Square)” In this study, researchers observed that treatment with Agaricus subrufescens ethanolic extract improved blood glucose, testosterone levels, and menstrual irregularity in rat models of letrozole-induced Polycystic Ovarian Syndrome, also noting a decrease in elevated liver and ovary weights, suggesting protective effects on renal function.
October 2004 in “Australian Prescriber” This review discusses the lack of long-term clinical studies on metformin's cardiovascular benefits in women with polycystic ovary syndrome, highlighting lifestyle changes as a crucial management strategy for reducing associated risks.
April 2023 in “Journal of Investigative Dermatology” In this study, a novel AR protein degrader was shown to reverse DHT-induced hair regrowth delay in a mouse model of androgenetic alopecia, with minimal circulation and potential side effects.
November 2022 in “Journal of Herbal Medicine” This study suggests that three mushroom-derived bioactive compounds, Zhankuic acid A, Sterenin M, and Melleolide K, may effectively inhibit SRD5A2 and stabilize its interaction, indicating potential for treating androgenic alopecia.
March 2022 in “Japanese Journal of Complementary and Alternative Medicine” In this case study, a novel treatment combining basal stone therapy and placenta extract applied to the scalp improved hair loss in a 46-year-old man resistant to typical home-care treatments for androgenic alopecia.
March 2022 in “Research Square (Research Square)” This study found that certain bioactive mushroom metabolites may inhibit the enzyme SRD5A2 more effectively than finasteride in computational models, suggesting potential for further research in treating androgenic alopecia.
August 2021 in “Journal of Investigative Dermatology” In this study, activated PRP injections appeared to promote hair growth in AGA-affected scalp skin transplanted onto mice, compared to non-activated PRP.
June 2021 in “Aesthetic Surgery Journal” This study did not report conclusive results on whether a higher dose of platelets in platelet-rich plasma treatment impacts hair density, emphasizing the need for further evaluation of the trial details.
January 2020 in “Hair transplant forum international” Oral minoxidil helps female hair loss, topical finasteride treats AGA, and sulfotransferase activity predicts minoxidil effectiveness.
This study observed that both 15% topical Minoxidil and low-level laser therapy increased patient satisfaction in treating androgenetic alopecia, but physician satisfaction was higher for Minoxidil, despite it causing more side effects.
January 2019 in “Journal of clinical and cosmetic dermatology” This article discusses the potential of combining growth factor therapy with LLLT LED therapy for hair regrowth in androgenetic alopecia, but it does not report new clinical results.
Androgenetic alopecia (AGA) is a common, hereditary hair loss condition that can be slowed but not permanently reversed with available therapies.
March 2017 in “European Urology Supplements” This study found that variations in (CAG)n and (GGN)n polymorphisms in the androgen receptor gene appear to influence symptom severity in men with post-finasteride syndrome.
August 2014 in “Journal of clinical & experimental dermatology research” This study outlines a hair regrowth treatment targeting hair follicle stem cells, 5-alpha reductase pathway, and microinflammation using PDGF and VEGF, but reports no clinical results.
97 citations
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September 2006 in “Pharmaceutical Research” This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.
24 citations
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November 2013 in “Trends in pharmacological sciences” This article describes a potential novel approach to reduce chemotherapy-induced hair loss by enhancing the expression of specific transporters in hair follicles, but reports no clinical results.
17 citations
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July 1995 in “International Journal of Dermatology” This study observed that local injection of minoxidil effectively prevented Ara-C-induced alopecia in newborn rats, while topical application was ineffective.
7 citations
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September 2021 in “Dermatology and Therapy” This review examines the implications of COVID-19 vaccination for dermatological patients with psoriasis on immunosuppressive treatment and reports no new clinical results.
6 citations
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May 2007 in “Forensic Science Medicine and Pathology” This study found that Minoxidil can interfere with hair drug analysis for cocaine by producing peaks that obscure the detection of cocaine and its metabolites in chromatograms.
1 citations
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January 1998 in “International journal of cancer” In this mouse study, topical 1,25-dihydroxyvitamin D3 protected against cyclophosphamide-induced hair loss and inhibited mammary tumor growth, with effects varying by sex and tumor presence.
July 2026 in “Journal of the American Academy of Dermatology”
June 2026 in “Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi” This study observed that biodegradable PVA/agar films with incorporated Achillea millefolium L. essential oil, especially at 1% (v/v), demonstrated good mechanical performance and selective antibacterial activity against E. coli, suggesting their potential as wound dressings.
January 2026 in “Journal of Ayurveda and Integrated Medical Sciences” This study discusses the potential health risks associated with long-term exposure to chemicals in cosmetics, like cancer and reproductive disorders, and examines Ayurvedic remedies that may mitigate these effects by countering a type of reduced potency poison known as Dushivisha.
In this study, minoxidil combined with PRP was found to effectively increase hair density in women with female pattern hair loss, but showed no superiority over minoxidil alone. No major side effects were reported.
In scalded rats, this study found that early melatonin administration may reduce oxidative stress and inflammation, thus protecting hair follicle cells after severe burns.
11 citations
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March 2020 in “American Journal of Medical Genetics Part A” This study identified a novel homozygous EDNRA variant linked to Oro-Oto-Cardiac Syndrome and showed that EDNRA signaling is essential for normal craniofacial and cardiovascular development.
215 citations
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March 2011 in “Clinical Cancer Research” This study found that sorafenib was active against desmoid tumors, with 25% of patients achieving a partial response and 70% maintaining stable disease.
182 citations
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June 2002 in “Journal of Neuroscience” This study suggests that apoE4 may contribute to cognitive decline by reducing androgen receptor levels in the brain, but androgen treatment improved memory deficits in female mice expressing human apoE4.
61 citations
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July 2022 in “Journal of Nanobiotechnology” This study found that carbon dots derived from fucoidan effectively inhibit Enterococcus faecalis and its biofilm, offering a promising approach for managing biofilm-associated persistent endodontic infections.
49 citations
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January 2021 in “Journal of The European Academy of Dermatology and Venereology” Anti-androgens, like finasteride, dutasteride, and spironolactone, may lessen the severity of COVID-19 in men, leading to fewer ICU admissions.