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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Finasteride reduces movement issues in Parkinson's disease rats.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Finasteride may cause kidney damage.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Taking both finasteride and dutasteride for prostate issues may raise the risk of heart problems.

Finasteride doesn't affect sleep spindles in men.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Rats had lasting erectile problems after stopping a certain medication.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.