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Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Finasteride effectively treats male hair loss, improving growth and density.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Plant-based treatments can effectively and safely treat hair loss.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Finasteride doesn't affect ovulation in normal women.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

Testosterone helps human pancreatic cells increase insulin release.