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This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.

This study found that Eclipta alba extracts exhibit 5α-reductase inhibitory activity, with the methanolic extract showing a higher concentration of β-sitosterol compared to petroleum ether extract, indicating potential for treating androgenic conditions like male pattern baldness.

This article reviews updates on 5 alpha-reductase inhibitors for treating male pattern hair loss and presents no new clinical findings; the author aims to enhance understanding of these therapies.

This study observes the expression of mRNA for androgen receptor, 5α‐reductase, and 17β‐hydroxysteroid dehydrogenase in human dermal papilla cells.

This review discusses advances in molecular biology and genetics related to androgenetic alopecia and reports no new clinical results.

In this study, researchers successfully established immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia patients, observing distinct gene expression, androgen receptor levels, and hair follicle growth effects between these regions, which may help advance hair loss research and therapeutic development.

This commentary discusses how common latent viruses might contribute to male-pattern baldness through mechanisms involving transcription factor deficiency and overexpression of specific proteins, based on a concept called microcompetition; it reports no new research results.

This review discusses the mechanisms of androgenic alopecia and reports no new results; the development of a mouse model for further study is described.

This review provides an overview of clinically approved small molecule drugs targeting androgen receptors and discusses therapeutic applications, without presenting new experimental results.

This study found that Lepidium sativum seed extract showed potential in treating alopecia in rats by reducing 5(alpha)-dihydrotestosterone levels and improving hair length compared to minoxidil.

This study developed a theoretical model that suggests finasteride may completely inhibit 5AR type 2, but not sufficiently suppress type 1, leading to only partial reduction of dihydrotestosterone at clinical doses.

This review describes the shift in treating symptomatic benign prostatic hyperplasia from surgery to 5alpha-reductase inhibitor drugs, which may provide symptom relief and alter BPH's progression, but reports no new clinical results.

This study found that in male Wistar rats, finasteride administration reduced neural cellular activity markers and 5-alpha reductase type 2 expression in brain tissue, with some recovery occurring after drug withdrawal, unlike persistent 5-alpha reductase type 2 suppression.

This study found that components derived from Uromedic® pumpkin seeds, especially Δ7-sterols, may inhibit DHT production and AR binding, potentially benefiting prostate and bladder health by moderating these mechanisms.

This study identified enzymes responsible for regulating androgen action in the human prostate, suggesting that inhibiting AKR1C2 or RL-HSD may have therapeutic potential in androgen insufficiency or benign prostatic hyperplasia, respectively.

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

This study found that various steroids affected the mRNA expression of enzymes involved in lipid metabolism in hamster flank organs, with different impacts depending on the steroid and combination used.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

This study reports that Hair RiseTM microemulsion, made from plant extracts, significantly enhanced hair follicle cell growth and improved hair growth signaling pathways, suggesting it as a plant-based alternative for androgenetic alopecia treatment.

This review suggests that linoleic acid, an essential fatty acid, may have various beneficial effects on skin health and hair growth through diverse biological activities observed in animal or skin cell models.

This study examined finasteride, a 5-alpha-reductase inhibitor, for treating a Tourette’s syndrome patient unresponsive to traditional therapy, noting its limited side effects.

Genes and hormones cause hair loss, with four genes contributing equally.

This study evaluated novel steroids' potential as future hormonal therapies for neuroprotection in glucose disorders, but emphasized that further research is needed to optimize androgen antagonist use in the context of COVID-19 progression.

This study found that a topical solution of caffeine and minoxidil 2.5% was more effective in treating androgenetic alopecia than minoxidil 2.5% alone.

Dutasteride 0.5mg was found to be more effective than finasteride 1mg in treating male pattern hair loss, with similar side effects.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This study found that glioblastoma cells express key enzymes involved in androgen synthesis, suggesting these enzymes might be potential targets for new therapeutic strategies.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This study suggests that certain Dibenzo derivatives may be promising candidates for prostate cancer treatment due to their potential interactions with the androgen receptor and 5α-reductase enzyme.

This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.