Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity

    December 2025 in “ Current Issues in Molecular Biology ”
    David Calderón Guzmán, Norma Osnaya Brizuela, Hugo Juárez Olguı́n … Diego Ortega
    Studysummary This study evaluated novel steroids' potential as future hormonal therapies for neuroprotection in glucose disorders, but emphasized that further research is needed to optimize androgen antagonist use in the context of COVID-19 progression.
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    Research cited in this study 8

    1. Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients 2022
    2. Do Anti-Androgens Have Potential as Therapeutics for COVID-19? Endocrinology · 2021
    3. Androgens and Antiandrogens Influence on COVID-19 Disease in Men Problemy e̊ndokrinologii · 2020
    4. A Systematic Review of Antiandrogens and Feminization in Transgender Women Clinical endocrinology · 2020
    5. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    6. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003
    7. Dihydrotestosterone And The Role Of 5α-Reductase Inhibitors In Benign Prostatic Hyperplasia Der Urologe · 2002
    8. Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition The Prostate · 1993