Use of Spironolactone in Dermatology

The review from 12 years ago discussed the use of spironolactone in dermatology. Spironolactone, a synthetic 17-lactone steroid, was initially used as a potassium-sparing diuretic. However, its antiandrogenic effects were discovered accidentally, leading to its use in treating dermatologic conditions where androgen plays a role in the pathogenesis. The antiandrogenic effects of spironolactone are achieved by reducing testosterone production and inhibiting its action on target tissues. The drug was primarily used as a medical treatment for hirsutism and female pattern hair loss, requiring continuous treatment to maintain its effect. It was also an effective alternative treatment for acne in women and had a long-term safety profile. However, spironolactone was not recommended for use in pregnancy due to its teratogenic effects and was not used in men due to the risk of feminization.