12 citations
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June 2001 in “Bioorganic & Medicinal Chemistry” Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
12 citations
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April 1995 in “Journal of Medicinal Chemistry” The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
11 citations
,
January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology” LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.
10 citations
,
August 2014 in “Skin research and technology” Sleep, testosterone levels, and a specific enzyme activity affect skin oil production in women.
10 citations
,
August 1998 in “Journal of Investigative Dermatology” The compounds tested could potentially treat hair loss and alopecia.
9 citations
,
January 2022 in “Biology” Male mice are more susceptible to autism-like changes from valproic acid than female mice.
9 citations
,
January 2005 in “Bioorganic & Medicinal Chemistry Letters” New compounds were made that effectively block enzymes related to prostate issues and hair loss.
8 citations
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August 2017 in “Steroids” New chemical compounds were made that effectively block an enzyme linked to prostate growth.
8 citations
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March 2002 in “Archiv Der Pharmazie” The compound 4c effectively inhibits the enzyme linked to hair loss.
7 citations
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August 1996 in “The Journal of Clinical Endocrinology and Metabolism”
6 citations
,
March 2022 in “JAAD International” Higher doses of isotretinoin may lead to more hair loss.
6 citations
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January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” A new compound shows promise as a topical treatment for hair loss.
6 citations
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July 2007 in “Organic Process Research & Development” Alcoholic solvent improves selectivity in key intermediate for finasteride and dutasteride synthesis.
5 citations
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October 1999 in “Journal of The American Academy of Dermatology”
5 citations
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February 1997 in “Bioorganic & Medicinal Chemistry” New compounds were made that effectively block a specific enzyme related to androgen conditions.
4 citations
,
March 2020 in “Journal of Cosmetic Dermatology” Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.
4 citations
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October 2016 in “PubMed” Increasing the dosage of minoxidil can help hair regrowth in women who didn't respond to the standard treatment.
4 citations
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January 1998 in “Heterocycles” Researchers made two new compounds that could be used for medicine.
3 citations
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January 2019 in “Journal of Dermatology” The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.
3 citations
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September 2017 in “Bioorganic & medicinal chemistry letters” New compounds were made that are promising for prostate cancer therapy.
3 citations
,
January 1994 in “Toxicological Sciences” Finasteride causes abnormal growth in male mice cells at high doses.
2 citations
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March 2015 in “Toxicology and Environmental Health Sciences” Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.
2 citations
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January 2010 in “Hormone Molecular Biology and Clinical Investigation” Low dose finasteride decreases certain steroids, possibly increasing depression risk.
1 citations
,
April 2023 in “Langmuir” Damaged hair allows water to penetrate more easily, and fatty acids from shampoos can deposit on hair surfaces.
1 citations
,
May 2017 in “Journal of Investigative Dermatology” Higher minoxidil dose helps hair growth in non-responders without side effects.
1 citations
,
January 2015 in “Journal of Clinical Toxicology” Babies were mostly born healthy from fathers who took finasteride, but some pregnancies ended early; more research is needed.
1 citations
,
July 2012 in “British Journal of Dermatology” New treatments and management strategies for skin conditions like melanoma and Spitz naevi were discussed at the dermatologists' meeting.
1 citations
,
July 2012 in “EFSA journal” KF2BL20 does not have proven benefits for maintaining normal hair.
May 2024 in “The Journal of urology/The journal of urology” SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.
September 2023 Oral minoxidil is as effective and safe as topical minoxidil for treating female pattern hair loss.