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Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Certain drugs that block specific enzymes can help treat prostate diseases.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

New sulfur-containing steroid analogs show promise for more targeted medical treatments.

New compounds may soon be tested to treat excessive hair growth in women.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Finasteride can cause muscle pain and high creatine kinase levels, but stopping the medication may resolve symptoms.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Researchers made two new compounds that could be used for medicine.

Castration and finasteride lower urinary oxalate in male rats, potentially treating urolithiasis.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.