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    Glossary 17-hydroxyprogesterone

    steroid hormone involved in cortisol and sex hormone production

    17-hydroxyprogesterone (17-OHP) is a steroid hormone produced in the adrenal glands and gonads as part of the process of synthesizing cortisol and other hormones. Elevated levels of 17-OHP can indicate congenital adrenal hyperplasia (CAH), a genetic disorder affecting hormone production, and it is often measured in newborn screening tests to diagnose this condition early.

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    1. Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone) The Journal of Clinical Endocrinology & Metabolism · 1975 · 96 citations
    2. 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Disclose Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2007 · 42 citations
    3. The diagnosis of nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, based on serum basal or post-ACTH stimulation 17-hydroxyprogesterone, can lead to false-positive diagnosis Clinical Endocrinology · 2015 · 25 citations
    4. Steroid 17-Hydroxyprogesterone in Hair Is a Potential Long-Term Biomarker of Androgen Control in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency Neuroendocrinology · 2019 · 10 citations
    5. Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia Clinical Endocrinology · 2016 · 9 citations
    6. Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature Case reports in endocrinology · 2019 · 7 citations
    7. Unusual presentation with polymenorrhagia and markedly high 17-hydroxy progesterone levels in a lady with Non-Classic Congenital Adrenal Hyperplasia. PubMed · 2015 · 1 citations
    8. Affect of a six months treatment regiment of metformin (MET) on 17-hydroxyprogesterone (17P) responses to GnRH agonist (GnRH Ag) in polycystic ovary syndrome (PCOS) Fertility and sterility · 2002
    9. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    10. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 Endocrine Practice · 2015 · 343 citations
    11. Screening for 21-hydroxylase–deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study Fertility and Sterility · 1999 · 216 citations
    12. A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia among Women Presenting with Hyperandrogenic Symptoms and Signs The Journal of Clinical Endocrinology and Metabolism · 2007 · 150 citations
    13. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    14. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    15. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    16. Androgen Profiling by Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) in Healthy Normal-Weight Ovulatory and Anovulatory Late Adolescent and Young Women The Journal of Clinical Endocrinology and Metabolism · 2013 · 52 citations
    17. Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane Veterinary dermatology · 2004 · 52 citations
    18. Apparent Cortisone Reductase Deficiency: A Rare Cause of Hyperandrogenemia and Hypercortisolism Hormone Research in Paediatrics · 2000 · 41 citations
    19. Treatment of canine Alopecia X with trilostane Veterinary Dermatology · 2004 · 40 citations
    20. Carriers of 21-Hydroxylase Deficiency Are Not at Increased Risk for Hyperandrogenism* The Journal of Clinical Endocrinology and Metabolism · 1997 · 31 citations
    21. Alopecia attributed to neoplastic ovarian tissue in two ferrets. PubMed · 2003 · 26 citations
    22. Does Cyclosporin A Influence Sex Hormone Level? Experimental and Clinical Endocrinology & Diabetes · 2009 · 20 citations
    23. Evaluation and Treatment of Hirsutism in Premenopausal Women JAMA · 2018 · 19 citations
    24. Hyperandrogenemia in women with polycystic ovary syndrome: prevalence, characteristics and association with body mass index Hormone Molecular Biology and Clinical Investigation · 2017 · 19 citations
    25. Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status European journal of endocrinology · 1999 · 19 citations
    26. Isosexual Precocious Pseudopuberty Secondary to a Testosterone-Secreting Leydig Cell Testicular Tumour: True Isosexual Development Early After Surgery* Andrologia · 2009 · 17 citations
    27. MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis European Journal of Endocrinology · 2018 · 16 citations
    28. The Use of Trilostane for the Treatment of Alopecia X in Alaskan Malamutes 2005 · 15 citations
    29. Clinico-investigative profile of patients of hirsutism in a tertiary level institution International Journal of Trichology · 2012 · 13 citations
    30. Estudio de patrones de implantación pilosa frontal en la mujer española caucásica Actas Dermo-Sifiliográficas · 2013 · 10 citations