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Glossary Androgen Receptor Antagonists

block male hormones like testosterone from affecting tissues

Androgen Receptor Antagonists, also known as antiandrogens, are medications that block the action of androgens, which are male sex hormones like testosterone. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects on tissues, and are commonly used in the treatment of conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and certain types of acne.

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Research

5 / 1000+ results

Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.

research Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth

8 citations , October 2016 in “Journal of Investigative Dermatology”

This study found that using mineralocorticoid receptor antagonists with glucocorticoid therapy improved wound healing in diabetic animals by enhancing keratinocyte proliferation and epithelialization.

research Pantolactams as androgen receptor antagonists for the topical suppression of sebum production

5 citations , September 2011 in “Bioorganic & Medicinal Chemistry Letters”

This study identified pantolactam based compounds as effective topical antagonists of the androgen receptor, reducing sebum components in a hamster model.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

1 citations , January 2019 in “Skin Pharmacology and Physiology”

This study found that inhibiting mineralocorticoid receptor signaling in female human hair follicles may promote hair growth by extending the anagen phase and encouraging keratinocyte proliferation.

Novel Dual Soft Drug Strategy Enables Development of Topical Androgen Receptor Antagonists with Enhanced Efficacy and Optimized Safety for Androgenetic Alopecia

research Novel DualSoftDrug Strategy Enables Developmentof Topical Androgen Receptor Antagonists with Enhanced Efficacy andOptimized Safety for Androgenetic Alopecia

July 2026 in “Figshare”

In this study, the researchers reported that the optimized compound 39 demonstrated potent AR antagonism and favorable pharmacokinetics in a hair-growth mouse model, achieving similar efficacy to pyrilutamide with faster onset and preserved safety, offering promise for next-generation topical AR antagonist development.

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Community Join

5 / 819 results

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

2 upvotes 1 year ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community How is the GT20029 different to pyrilutamide as an androgenic antagonist

1 year ago

GT20029 and pyrilutamide are both androgen antagonists but work differently; GT20029 degrades the androgen receptor, while pyrilutamide blocks DHT from binding. GT20029 is expected to have similar efficacy to CosmeRNA.

community Anyone know by what percentage Pyrilutamide or Ru decrease your androgens?

in Chat 1 upvotes 1 year ago

Pyrilutamide and RU58841 are androgen receptor antagonists that block receptors without significantly reducing testosterone or DHT levels. Any indirect effect on androgen levels is likely negligible.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Pyrilutamide for Hair Loss!? (Ft. Steve Cook)

in Satire 4 upvotes 4 months ago

Pyrilutamide is discussed as a potential hair loss treatment, acting as an androgen receptor antagonist. The conversation questions if it can maintain hair long-term without using finasteride.

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Learn

6 / 801 results

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn HMI-115

What is HMI-115 and how is it different from common treatments like minoxidil? HMI-115 (BAY 1158061) is an investigational monoclonal antibody that blocks the prolactin receptor, not a GnRH antagonist. It is given by injection in trials and is not approved anywhere; minoxidil is an approved topical vasodilator with decades of published data, while HMI-115's hair-loss trial results remain unpublished.

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Overview

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