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Glossary Androgens

group of sex hormones influencing male traits and reproduction

Androgens are a group of sex hormones, including testosterone, that play a crucial role in male traits and reproductive activity. They are responsible for the development of male characteristics such as facial hair, deepening of the voice, and muscle growth, but are also present in females in smaller amounts, influencing hair growth and libido.

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Research

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research Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives

233 citations , November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations , July 1998 in “Journal of Cutaneous Medicine and Surgery”

This study found that shorter CAG-repeat lengths in the androgen receptor may be associated with the development of androgen-mediated skin disorders like androgenetic alopecia, acne, and hirsutism in both men and women.

research How should postmenopausal androgen excess be evaluated?

63 citations , March 2011 in “Clinical Endocrinology”

This review examines the evaluation and management of hirsutism and hyperandrogenism in postmenopausal women and reports no new clinical findings.

research Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

23 citations , June 2006 in “Journal of Investigative Dermatology”

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

research Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis

17 citations , February 2003 in “Australasian Journal of Dermatology”

This review discusses ovarian hyperthecosis as a rare cause of androgenetic alopecia in postmenopausal women and reports no new results; the authors highlight the need to explore its relationship to alopecia further.

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Community Join

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community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community Female androgenetic alopecia (w/ PCOS) starting treatment

4 upvotes 1 year ago

A female with PCOS and androgenetic alopecia is starting treatment with oral Minoxidil, topical Minoxidil 5% with finasteride, and plans to add mesotherapy. She previously tried anti-androgenic contraceptive pills but couldn't tolerate them and is using Myo Inositol for weight management.

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Learn

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learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Saw Palmetto

Is saw palmetto good for androgenetic alopecia or only for mild hair loss? Evidence is weak and mostly in men with mild to moderate hair loss. In the one comparison study, fewer men improved on saw palmetto than on finasteride.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Fluridil

Is Fluridil only for men with androgenetic alopecia, or can women use it too? The only published clinical study of fluridil enrolled 43 men, so its use in women is untested rather than established; women considering it should talk to a doctor, and it is not advised in pregnancy or breastfeeding because no reproductive-safety data exists.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Clascoterone

An androgen-receptor blocker approved only for acne (Winlevi 1% cream). A scalp solution is still investigational for hair loss; its sponsor reports positive Phase III results in men, not yet peer-reviewed.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Azelaic Acid

acne and rosacea medicine with laboratory anti-androgen activity and one small hair-loss trial

learn GT20029

Investigational compound designed to degrade androgen receptors in the scalp; not approved or sold anywhere.

learn Spironolactone

A prescription blood-pressure and diuretic drug with anti-androgen effects, used off-label mainly by women for pattern hair loss.

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