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Glossary Circulating Androgens

male sex hormones present in the bloodstream

Circulating androgens are male sex hormones, such as testosterone, that are present in the bloodstream. These hormones play a crucial role in the development of male characteristics, but they are also found in females in smaller amounts. Elevated levels of circulating androgens can influence hair growth patterns and are often linked to conditions like androgenetic alopecia (pattern hair loss) and hirsutism (excessive hair growth).

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Research

5 / 1000+ results

research Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

37 citations , February 2023 in “Gut Microbes”

This study found that administering the gut bacterium Thauera sp. strain GDN1 to mice significantly reduced their serum androgen levels, indicating gut bacteria may influence androgen metabolism.

research Circulating Androgen Concentrations and Risk of Incident Heart Failure in Older Men: The Cardiovascular Health Study

14 citations , October 2022 in “Journal of the American Heart Association”

This study found that among older men, lower calculated free testosterone was significantly associated with a higher risk of heart failure, suggesting a possible role of testosterone deficiency in heart failure incidence.

research Association Between Circulating Androgens and Androgenetic Alopecia in Adult Males: A Systematic Review

January 2026 in “Dermatologic Therapy”

This review found that circulating dihydrotestosterone (DHT) consistently distinguishes men with androgenetic alopecia from controls, suggesting a key role in the condition's biology and potential therapeutic targeting.

research Circulating androgen levels before and after oophorectomy in premenopausal and postmenopausal women

22 citations , January 2019 in “Climacteric”

This study reports that oophorectomy significantly reduces serum testosterone levels in postmenopausal women, indicating the postmenopausal ovary's continued production of testosterone.

research Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

2 citations , July 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that oral administration of Thauera sp. strain GDN1 reduced serum androgen levels in male mice by about 50%, suggesting its potential as a probiotic treatment for hyperandrogenism.

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Learn

7 / 7 results

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Small studies have found that metformin lowers circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

learn Rosemary

Herb whose oil is used in hair care

Does rosemary improve scalp circulation, and would that regrow hair? No study has measured whether rosemary improves scalp blood flow in people. Its hair evidence is one small trial without a placebo arm, plus mouse and lab studies.

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn capsicum

Does capsicum improve scalp circulation or hair growth? Capsaicin dilates blood vessels through TRPV1 activation, so in theory capsicum could raise scalp blood flow (this has not been measured on the scalp in a hair-loss study), but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.

learn Ginkgo biloba

Does ginkgo biloba improve scalp circulation, and does that help hair regrowth? No human study has shown that ginkgo improves scalp circulation or regrows hair; the direct hair evidence is a 1993 mouse study. Ginkgo may increase bleeding risk, especially with blood thinners.

learn Vitis vinifera

Can grape extract help with scalp circulation or hair growth? There is no human evidence that grape extract improves scalp blood flow or hair growth; the related data are on blood pressure and in mice.

Community Join

5 / 318 results

community What actually causes hair loss / androgenic alopecia?

in Chat 8 upvotes 1 year ago

DHT sensitivity at the scalp increases with age, contributing to androgenic alopecia. Treatments like Minoxidil, finasteride, and RU58841 are discussed for managing hair loss.

community Why doctors are contradictory when it comes to Androgenetic alopecia?

5 upvotes 3 years ago

The conversation discusses androgenetic alopecia (AGA) and questions why treatments focus on lowering DHT levels instead of building resistance to it. It also touches on hair transplantation techniques using body hair.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Best science-backed supplements for androgenetic alopecia? Looking for real evidence

8 months ago

The conversation discusses treatments for androgenetic alopecia, focusing on evidence-based supplements to complement finasteride. Suggestions include oral minoxidil, saw palmetto, pumpkin seed oil, tocotrienols, and various other supplements, while emphasizing the importance of scientific backing and cautioning against saw palmetto if already using finasteride.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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