The Role of Vitamin D and Its Receptor in Skin and Hair Follicle Biology

January 2011 in “ Elsevier eBooks ”

Marie B. Demay, Marie B. Demay

vitamin D vitamin D receptor VDR hair follicle biology keratinocyte cells gene expression signaling pathways cutaneous homeostasis hair cycle regeneration

TLDR Vitamin D and its receptor are crucial for skin and hair health.

The document discussed the role of vitamin D and its receptor (VDR) in skin and hair follicle biology. It highlighted that the skin was unique in its ability to synthesize vitamin D and respond to it through VDR-ligand interactions, affecting gene expression and signaling pathways. The research enhanced the understanding of VDR's mechanism and biological effects, particularly in hair follicle biology, where VDR actions were found to be ligand-independent in a specific population of keratinocyte cells. The study suggested that further characterization of VDR's molecular partners could reveal additional roles in maintaining hair cycle regeneration and cutaneous homeostasis.

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Research cited in this study

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research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

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research Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function

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research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

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Hairless protein can block vitamin D activation in skin cells.

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research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis

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research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

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The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

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research Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is crucial for normal skin and hair growth.

research Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia

115 citations , December 2001 in “Endocrinology”

Expressing the human vitamin D receptor in skin cells prevents hair loss in certain mice.

research The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

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The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

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research Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice

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Alopecia in these mice is caused by defective hair cycle communication due to missing vitamin D receptor function, not vitamin D levels.

research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice

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Alopecia in VDR knockout mice is due to a defect in hair cycle initiation, not keratinocyte issues.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

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Activated LEF/TCF complexes are crucial for hair development and cycling.

research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

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Activating the Sonic hedgehog gene in mice can start the hair growth phase.

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β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

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Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene

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A mutation in the human hairless gene causes alopecia universalis.

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Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

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The conversation discusses hair loss treatments, including oral finasteride, topical minoxidil, and microneedling, and the potential impact of Vitamin D and folic acid deficiencies on hair regrowth. It suggests that while male pattern baldness is the primary cause, addressing vitamin deficiencies may aid in improving regrowth.

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in Research/Science 10 upvotes 1 year ago

Topical Vitamin D3 may stimulate hair growth and has been used for Alopecia Areata. There is a question about the lack of research on its use for Androgenetic Alopecia (AGA).

community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

in Research/Science 64 upvotes 1 year ago

The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

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