Vitamin D and TMPRSS2: Intersecting Pathways in Post-COVID-19 Alopecia

    January 2026 in “ Journal of Contemporary Medicine ”
    İrem Hengirmen Acu
    Studysummary This narrative review explores mechanisms linking COVID-19 with hair loss, highlighting how cytokine-mediated inflammation, androgen-regulated TMPRSS2 expression, and direct follicular injury contribute to the condition. It suggests that vitamin D could potentially mitigate this hair loss by suppressing inflammation and viral entry, warranting further research.
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    Research cited in this study 25

    1. Post-COVID Telogen Effluvium: The Diagnostic Value of Serum Ferritin Biomarker and the Preventive Value of Dietary Supplements. A Case-Control Study Archives of dermatological research · 2024
    2. Prevalence of Telogen Effluvium Hair Loss in COVID-19 Patients and Its Relationship with Disease Severity Journal of medicine and life · 2022
    3. Complementary Strategies to Promote Hair Regrowth in Post-COVID-19 Telogen Effluvium Clinical, Cosmetic and Investigational Dermatology · 2022
    4. Association of Androgenetic Alopecia with a More Severe Form of COVID-19 Infection Irish Journal of Medical Science · 2022
    5. Alopecia in Patients with COVID-19: A Systematic Review and Meta-Analysis JAAD International · 2022
    6. A Systematic Review of Acute Telogen Effluvium, a Harrowing Post-COVID-19 Manifestation Journal of Medical Virology · 2021
    7. COVID-19 Infection: Impact on Hair Indian Journal of Plastic Surgery · 2021
    8. Androgenetic Alopecia and COVID-19: A Review of the Hypothetical Role of Androgens Dermatologic Therapy · 2021
    9. A Case of Acute Telogen Effluvium After SARS-CoV-2 Infection Clinical, Cosmetic and Investigational Dermatology · 2021
    10. Telogen Effluvium After SARS-CoV-2 Infection: A Series of Cases and Possible Pathogenetic Mechanisms Skin appendage disorders · 2021
    11. Anti-Androgens May Protect Against Severe COVID-19 Outcomes: Results From a Prospective Cohort Study of 77 Hospitalized Men Journal of The European Academy of Dermatology and Venereology · 2021
    12. Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients Journal of the European Academy of Dermatology and Venereology · 2020
    13. Polycystic Ovary Syndrome (PCOS) and COVID-19: An Overlooked Female Patient Population at Potentially Higher Risk During the COVID-19 Pandemic BMC Medicine · 2020
    14. Androgen Sensitivity Gateway to COVID-19 Disease Severity Drug Development Research · 2020
    15. The Importance of Vitamin D in Androgenic Alopecia and Telogen Effluvium Қазақстанның клиникалық медицинасы · 2018
    16. Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells Frontiers in Cellular and Infection Microbiology · 2018
    17. An Investigation of Vitamin D Status in Alopecia Areata Clinical and Experimental Medicine · 2018
    18. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    19. Vitamin D Deficiency in Patients With Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2017
    20. Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction Journal of Dermatological Science · 2017
    21. Vitamin D Deficiency in Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2014
    22. Androgenetic Alopecia: Overview, Epidemiology, Pathophysiology, and Treatment Journal of the Egyptian Women's Dermatologic Society (Print) · 2013
    23. Vitamin D Concentrations Are Decreased in Patients with Alopecia Areata Vitamins & Trace Elements · 2012
    24. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    25. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata British Journal of Dermatology · 2010