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This narrative review explores mechanisms linking COVID-19 with hair loss, highlighting how cytokine-mediated inflammation, androgen-regulated TMPRSS2 expression, and direct follicular injury contribute to the condition. It suggests that vitamin D could potentially mitigate this hair loss by suppressing inflammation and viral entry, warranting further research.

Men have worse COVID-19 outcomes than women due to genetic and hormonal differences.

This review discusses the link between androgen receptor action and TMPRSS2 expression in severe COVID-19, exploring the potential of anti-androgens to mitigate disease severity in men and notes ongoing trials.

This study identifies SOX9 as a critical downstream effector of ERG in TMPRSS2:ERG fusion-positive prostate cancer, indicating its role in tumor invasion and growth.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.