TLDR Metformin, usually used for diabetes, can also help treat hair loss from alopecia areata due to its ability to reduce inflammation and stimulate new hair growth.
Metformin, a common treatment for type 2 diabetes, may also be effective in treating alopecia areata, an autoimmune disease causing hair loss. Metformin's immunomodulatory properties can reduce inflammation and autoimmunity in alopecia areata through several mechanisms, including inhibiting the mTOR and JAK-STAT pathways, promoting cellular autophagy, and increasing the cellular AMPK enzyme. These actions decrease inflammatory cell proliferation and cytokine production, key factors in alopecia areata's pathogenesis. Metformin can also stimulate new hair growth by inducing autophagy and stem cell production. Topical application of metformin has been linked to minor side effects like scalp dryness and irritation, but no systemic side effects have been reported. Given its availability and affordability, metformin could be a beneficial treatment for alopecia areata.View this study on doi.org →
Metformin helps lab-grown skin and hair cells work better to create hair.
Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.
Metformin, usually used for diabetes, can also help treat hair loss from alopecia areata due to its ability to reduce inflammation and stimulate new hair growth.
Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.
Low vitamin D levels are linked to various types of hair loss, but more research is needed before using it as a treatment.
Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.
Miniaturized hairs stay connected to muscle in alopecia areata, allowing possible regrowth, but not in androgenetic alopecia.