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research Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation

4 citations , January 2019 in “Journal of cutaneous pathology”

This study found that phospho-S6 is strongly expressed in malignant hair follicle tumors but only patchily in a minority of benign tumors, indicating a potential marker for distinguishing between the two.

research Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?

18 citations , January 2009 in “Experimental Dermatology”

This study proposes that mammalian target of rapamycin (mTOR) may connect various signaling pathways in hair follicle tumor formation, offering a potential unified model for understanding these tumors.

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

This study observed high expression of mTOR pathway effectors in fibrous papules and TSC-associated angiofibromas, suggesting that topical rapamycin might be an effective treatment for fibrous papules.

research The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

177 citations , March 2018 in “International Journal of Molecular Sciences”

This review discusses the role of mTOR kinase in pulmonary fibrosis and explores how mTOR inhibitors may help slow the progression of this condition, but it reports no new results.

research Topical metformin as a novel therapy for alopecia areata due to its immunologic effects

August 2023 in “Medical Hypotheses”

In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

What is rapamycin, and how is it being studied as a potential treatment for hair loss? Rapamycin is being studied for hair loss due to its effects on the mTOR pathway.
Can rapamycin be combined with other treatments like minoxidil or finasteride for better results? There are no published human trials of rapamycin combined with minoxidil or finasteride; the case for combining them is mechanistic theory only, and rapamycin for hair loss remains an off-label use of an immunosuppressant, so any combination is a decision for a prescriber.
Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

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Clinics

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Hair Loss Treatments
Pathway Health & Wellness, Mesa, AZMesa, AZ · US

Experts

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94
Hair Transplant Surgeon
Dr. Rahma Targett, MD, FRACGP
Adelaide, SA, Australia

Dr. Rahma Targett, MD, FRACGP