Treatment Outcomes and Considerations for Topical Immunotherapy in Patients with Alopecia Totalis and Alopecia Universalis

    July 2025 in “ Frontiers in Medicine ”
    Taiyo Hitaka, Sanehito Haruyama, Shun Ohmori … Yu Sawada
    Studysummary This study found that topical immunotherapy is effective for treating severe alopecia areata, though patient responses can vary, highlighting the importance of individualized treatment approaches and prolonged therapy to optimize outcomes.
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    Research cited in this study 16

    1. Local Corticosteroids for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    2. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    3. Treatments for Alopecia Areata: A Network Meta-Analysis The Cochrane library · 2023
    4. Janus Kinase Inhibitors for Alopecia Areata Journal of the American Academy of Dermatology · 2023
    5. Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases Journal of Clinical Medicine · 2023
    6. Alopecia Areata: An Updated Review for 2023 Journal of Cutaneous Medicine and Surgery · 2023
    7. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    8. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    9. Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update Drug design, development and therapy · 2021
    10. Consensus on the Treatment of Alopecia Areata – Brazilian Society of Dermatology Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2020
    11. Efficacy of Antihistamines in Combination with Topical Corticosteroid and Superficial Cryotherapy for Treatment of Alopecia Areata: A Retrospective Cohort Study Journal of the American Academy of Dermatology · 2020
    12. Italian Guidelines in Diagnosis and Treatment of Alopecia Areata Giornale italiano di dermatologia e venereologia · 2019
    13. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    14. Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata JAMA Dermatology · 2018
    15. A Systematic Review of Pulse Steroid Therapy for Alopecia Areata Journal of the American Academy of Dermatology · 2016
    16. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012

    Related research 5

    1. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    2. Linear Alopecia Areata JAAD case reports · 2018
    3. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018
    4. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    5. Overview of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013