The Role of Lipids in Promoting Hair Growth Through HIF-1 Signaling Pathway

This study investigates the role of lipids in hair growth, particularly through the HIF-1 signaling pathway. Researchers observed reduced lipid metabolism in the scalp tissues of patients with androgenetic alopecia. Supplementing lipids in culture mediums enhanced hair growth-related gene expression and the proliferation of human dermal papilla cells (DPCs). RNA-sequencing and HIF-1α knockdown experiments identified HIF-1α as a key regulator in lipid-induced upregulation of trichogenic genes. Additionally, in vitro tests with hair follicle organoids showed that lipids promoted the elongation of hair-shaft-like structures. These findings suggest that targeting lipid pathways could be a promising strategy for treating hair loss.