Skin Transcriptome Reveals Periodic Changes in Genes Underlying Cashmere Follicle Transition in Cashmere Goats

February 2020 in “ Research Square (Research Square) ”

Feng Yang, Zhihong Liu, Meng Zhao, Qing Mu, Tianyu Che, Yingxin Xie, Lina Ma, Lu Mi, hong Yan Zhao, Jinquan Li

secondary hair follicle hair follicle cycle KAP3-1 KRTAP 8-1 KRTAP 24-1 gene variations cashmere growth cycle hair follicle development

Studysummary In this study, the researchers identified key genes, including KAP and KRTAP, that correlate with the secondary hair follicle growth cycle in Inner Mongolian cashmere goats, emphasizing March as the significant transition month.

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The study investigated the molecular regulatory mechanisms of the secondary hair follicle growth cycle in Inner Mongolian cashmere goats by using transcriptome sequencing to analyze gene variations throughout the hair follicle cycle. The growth cycle of cashmere hair was divided into three periods: growth (March–September), regression (September–December), and resting (December–March), with March being a significant month for the cycle's initiation. Differential gene analysis and cluster analysis identified key nodes and genes, such as KAP3-1, KRTAP 8-1, and KRTAP 24-1, which had a close positive correlation with the cashmere growth cycle. The study concluded that these genes' regulation was consistent with the growth cycle of cashmere, and that hair follicle development-related genes are expressed earlier than cashmere growth, suggesting that cycle regulation could affect the timing of cashmere growth. This research provides a theoretical foundation for understanding the cashmere development cycle and identifying key genes involved in the transition through the cycle, which could benefit cashmere goat breeding.

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