Molecular Regulation of Secondary Hair Follicle Stem Cell by S100a4 in Cashmere Goat

    January 2026 in “ International Journal of Molecular Sciences ”
    Xinyue Liang, Bohan Liu, Jiayi Wang … Huiling Xue
    Studysummary In this study, researchers identified S100a4 as a critical regulator of secondary hair follicle stem cells in cashmere goats, linking its expression to follicle regeneration and differentiation pathways, which may have implications for enhancing cashmere fiber production.
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    Research cited in this study 10

    1. Transcriptional Signatures of Secondary Hair Follicles During Annual Cashmere Growth Scientific Data · 2024
    2. Discovery and Functional Analysis of Secondary Hair Follicle miRNAs During Annual Cashmere Growth International journal of molecular sciences · 2023
    3. Efficient Establishment of an Optimized Culture Condition for Cashmere Goat Primary Hair Follicle Stem Cells Journal of animal science/Journal of animal science ... and ASAS reference compendium · 2023
    4. Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep International Journal of Molecular Sciences · 2015
    5. Identification of Genes Influencing Formation of the Type III Brush Hair in Yangtze River Delta White Goats by Differential Display of mRNA Gene · 2013
    6. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    7. Significance of the S100A4 Protein in Psoriasis Journal of Investigative Dermatology · 2009
    8. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    9. Scratching the Surface of Skin Development Nature · 2007
    10. Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration Journal of Investigative Dermatology · 2001