Role of Skin Enzymes in Metabolism of Topical Drugs

    September 2024 in “ Metabolism and Target Organ Damage ”
    Nikki Lau, Khanh Phan, Yousuf Mohammed
    Studysummary This review discusses the role of skin enzymes in drug metabolism and emphasizes the need for models assessing enzyme activity to evaluate the safety and bioequivalence of topical generic drugs, highlighting efforts to standardize testing protocols for transdermal products.
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    Research cited in this study 7

    1. The Significance of CYP11A1 Expression in Skin Physiology and Pathology Molecular and Cellular Endocrinology · 2021
    2. Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells · 2020
    3. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    4. Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models Archives of Toxicology · 2018
    5. Anatomy and Physiology of the Skin Journal of the Dermatology Nurses’ Association · 2011
    6. Vitamin D Metabolism and Function in the Skin Molecular and cellular endocrinology · 2011
    7. Cytochrome P450: A Target for Drug Development for Skin Diseases ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004