Hair Follicle Associated Pluripotent Stem Cells Stimulate Hair Growth in Transplanted Mice

December 2022 in “ Scientific Reports ”

Koya Obara, Jose Reynoso, Yuko Hamada, Yusuke Aoki, Yutaro Kubota, Noriyuki Masaki, Yasuyuki Amoh, Robert M. Hoffman

Hair follicle associated pluripotent stem cells HAP stem cells hair growth transplantation athymic nu/nu nude mice FOXN1 gene hair follicles cell therapy hair-growth area hair length hair-density score stem cells nude mice

Studysummary This study found that transplanted hair follicle-associated pluripotent stem cells in mice differentiated into keratinocytes and stimulated hair growth by producing mature hair shafts.

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research Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls

8 citations , May 2021 in “Bioengineering & translational medicine”

This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.

research Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

30 citations , November 2020 in “Journal of Advanced Research”

This study found that conditioned medium from keratinocytes improved the hair-inductive properties of cultured dermal papilla cells, suggesting potential for enhancing hair follicle regeneration.

Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

22 citations , March 2020 in “Journal of The American Academy of Dermatology”

This study found that injecting autologous dermal sheath cup cells significantly increased hair density and diameter in male and female pattern hair loss compared to a placebo for up to 9 months.

research Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin

40 citations , June 2019 in “Biochemical and Biophysical Research Communications”

This study demonstrated that combining the Wnt/β-catenin activator CHIR99021 with 3D spheroid culture effectively enriched hair follicle formation in reconstituted human skin.

research Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model

77 citations , April 2016 in “Science Advances”

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration

research Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration

62 citations , February 2016 in “ACS Applied Materials & Interfaces”

This study found that 3D microtissue models of dermal papilla cells can enhance the ability to induce hair-follicle neogenesis in vivo, offering potential for controlled cell production in follicle regeneration.

research From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells

64 citations , May 2015 in “Cell Cycle”

This study found that hair follicle stem cells from mice can differentiate into beating cardiac muscle cells, suggesting potential applications for heart regeneration in regenerative medicine.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.

Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

256 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

research Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

78 citations , October 2012 in “Biomaterials”

This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.

research Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle

47 citations , August 2012 in “Cell Cycle”

This study found that multipotent, nestin-expressing stem cells from the upper part of hair follicles can proliferate significantly and differentiate into various cell types, showing potential for nerve and spinal cord repair.

research Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation

66 citations , May 2012 in “Scientific Reports”

This study demonstrated that bioengineered hair follicles reconstituted from embryonic skin cells and transplanted into hosts can restore physiological hair functions, suggesting potential applications for treating alopecia.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.

research Nestin Expression in Hair Follicle Sheath Progenitor Cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.