The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

    November 2019 in “ Scientific reports ”
    Gun He Nam, Kyung-Jo Jo, Ye-Seul Park … Young‐Min Kim
    Studysummary This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.
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    Research cited in this study 16

    1. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    2. Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway BMC Complementary and Alternative Medicine · 2019
    3. Stimulatory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Cultured Human Follicle Dermal Papilla Cells Food Science and Technology Research · 2018
    4. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    5. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    6. Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth PLOS ONE · 2016
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    9. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    10. Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain Journal of Dermatological Treatment · 2016
    11. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    12. Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro European Journal of Pharmacology · 2015
    13. Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride Indian Dermatology Online Journal · 2015
    14. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012
    15. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    16. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006

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