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GlossarymTOR pathway (mTORC1 signaling)

regulates cell growth and metabolism in response to nutrients

The mTOR pathway, short for the mechanistic target of rapamycin pathway, is a crucial cellular signaling pathway that regulates growth, metabolism, and survival in response to nutrients, growth factors, and other environmental cues. It plays a significant role in various biological processes, including cell proliferation, protein synthesis, and autophagy, and is implicated in conditions like cancer, diabetes, and neurodegenerative diseases.

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research Activation of mTORC1 Signaling Is Required for Timely Hair Follicle Regeneration from Radiation Injury

12 citations , October 2017 in “Radiation Research”

mTORC1 signaling needed for quick hair follicle recovery after radiation damage.

The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations , November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

research Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.AktWT Mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

research Millet Seed Oil Activates Beta-Catenin Signaling and Promotes Hair Growth

1 citations , May 2023 in “Frontiers in Pharmacology”

Millet seed oil may help hair grow by activating certain cell growth signals.

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community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 43 upvotes 8 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.