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GlossarymTOR pathway (mTORC1 signaling)

regulates cell growth and metabolism in response to nutrients

The mTOR pathway, short for the mechanistic target of rapamycin pathway, is a crucial cellular signaling pathway that regulates growth, metabolism, and survival in response to nutrients, growth factors, and other environmental cues. It plays a significant role in various biological processes, including cell proliferation, protein synthesis, and autophagy, and is implicated in conditions like cancer, diabetes, and neurodegenerative diseases.

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research Activation of mTORC1 Signaling Is Required for Timely Hair Follicle Regeneration from Radiation Injury

12 citations, October 2017 in “Radiation Research”

mTORC1 signaling needed for quick hair follicle recovery after radiation damage.

The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations, November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

research Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.AktWT Mice

8 citations, September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

71 citations, January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

research Millet Seed Oil Activates Beta-Catenin Signaling and Promotes Hair Growth

1 citations, May 2023 in “Frontiers in Pharmacology”

Millet seed oil may help hair grow by activating certain cell growth signals.

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