Multisystem Adverse Effects of Isotretinoin: Mechanistic Insights and Clinical Implications

    January 2026 in “ International Journal of Innovative Technologies in Social Science ”
    Marcin Chwalczuk, Klaudia Leszto, Franciszek Szweda … Kinga Augustyniak
    Studysummary This review synthesizes information on isotretinoin’s systemic toxicity, emphasizing that its adverse effects, including mucocutaneous, hepatic, and musculoskeletal reactions, primarily reflect its pharmacodynamic actions and are generally manageable with individualized dosing and monitoring, though its teratogenicity remains a significant safety concern.
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    Research cited in this study 8

    1. Guidelines of Care for the Management of Acne Vulgaris Journal of the American Academy of Dermatology · 2024
    2. Isotretinoin Treatment Upregulates the Expression of P53 in the Skin and Sebaceous Glands of Patients with Acne Vulgaris Archives of Dermatological Research · 2022
    3. Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis International Journal of Environmental Research and Public Health · 2022
    4. Consensus on the Use of Oral Isotretinoin in Dermatology - Brazilian Society of Dermatology Anais Brasileiros de Dermatologia · 2020
    5. FASCE: The Benefit of Spironolactone for Treating Acne in Women - Study Protocol for a Randomized Double-Blind Trial Trials · 2020
    6. Oral Isotretinoin for Acne Cochrane library · 2018
    7. Effects of Isotretinoin on the Hair Cycle Journal of Cosmetic Dermatology · 2018
    8. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity Acta dermato-venereologica · 2017