January 2026 in “International Journal of Innovative Technologies in Social Science” This review synthesizes information on isotretinoin’s systemic toxicity, emphasizing that its adverse effects, including mucocutaneous, hepatic, and musculoskeletal reactions, primarily reflect its pharmacodynamic actions and are generally manageable with individualized dosing and monitoring, though its teratogenicity remains a significant safety concern.
53 citations
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December 2012 in “Revista da Sociedade Brasileira de Medicina Tropical” In this study, liver transaminase levels and various symptoms persisted in some adult dengue patients even two months after diagnosis.
October 2011 in “The American Journal of Gastroenterology” This case report suggests a potential association between esomeprazole use and hepatic injury, highlighting a temporal relationship with liver enzyme elevation that resolved upon discontinuing the drug.
14 citations
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October 2020 in “Journal of ethnopharmacology” This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.
In this case report, a 45-year-old man with treatment-resistant androgenetic alopecia experienced hair regrowth during oral bicalutamide treatment but also suffered adverse effects leading to discontinuation, highlighting the need for further studies on the safety and role of androgen receptor blockade in hair loss.