FASCE: The Benefit of Spironolactone for Treating Acne in Women - Study Protocol for a Randomized Double-Blind Trial

    June 2020 in “ Trials ”
    Alexandra Poinas, M Lemoigne, S. Le Naour, Jean–Michel Nguyen, Solène Schirr-Bonnans, Valéry-Pierre Riche, Florence Vrignaud, L. Machet, Jean‐Paul Claudel, Marie‐Thérèse Leccia, E. Hainaut, N. Bénéton, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Anne Chiffoleau, Stéphane Corvec, Amir Khammari, Brigitte Dréno
    TLDR The trial aims to test if spironolactone is an effective acne treatment for women without the side effects of current treatments.
    The FASCE trial aimed to evaluate the efficacy of spironolactone compared to doxycycline in treating acne in women through a randomized double-blind study involving approximately 200 participants. The primary objective was to determine whether spironolactone could significantly reduce acne severity compared to doxycycline, with secondary objectives including safety, quality of life, and cost-effectiveness over 12 months. The study used the Adult Female Acne Scoring Tool (AFAST) for precise evaluation and included a detailed methodology for participant selection, dosage, and assessment criteria. The trial was designed to provide an alternative to antibiotics, addressing concerns about antibiotic resistance, and to offer insights into the optimal treatment duration and efficacy of spironolactone for acne.
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      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 3 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 4 months ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 8 months ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Spironolactone topically with a try ?!

      in Research/Science  1 upvotes 10 months ago
      A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 1 year ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

      community medication for hair loss spironolactone

      in Female  3 upvotes 1 year ago
      41-year-old female experienced slow hair thinning, took finasteride for a year, then switched to spironolactone. Irregular periods occurred, seeking advice on long-term side effects and considering a third medication.

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