TLDR The trial aims to test if spironolactone is an effective acne treatment for women without the side effects of current treatments.
The FASCE trial aimed to evaluate the efficacy of spironolactone compared to doxycycline in treating acne in women through a randomized double-blind study involving approximately 200 participants. The primary objective was to determine whether spironolactone could significantly reduce acne severity compared to doxycycline, with secondary objectives including safety, quality of life, and cost-effectiveness over 12 months. The study used the Adult Female Acne Scoring Tool (AFAST) for precise evaluation and included a detailed methodology for participant selection, dosage, and assessment criteria. The trial was designed to provide an alternative to antibiotics, addressing concerns about antibiotic resistance, and to offer insights into the optimal treatment duration and efficacy of spironolactone for acne.
117 citations
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February 2017 in “American Journal of Clinical Dermatology” Oral spironolactone's effectiveness for adult female acne is not well-supported by strong evidence.
96 citations
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September 2008 in “Seminars in Cutaneous Medicine and Surgery” Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.
research Acne
231 citations
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April 2005 in “The New England Journal of Medicine” Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.
78 citations
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January 2003 in “Dermatology” Hormonal therapy is becoming a promising treatment for acne.
101 citations
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January 1985 in “British Journal of Dermatology” Spironolactone is effective for treating acne, hirsutism, and androgenic alopecia in women with few side effects.
Spironolactone may be a better acne treatment for adult women than antibiotics.
2 citations
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January 2011 in “Elsevier eBooks” Early treatment of acne is crucial to prevent scarring and psychological effects.
11 citations
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February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.
90 citations
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April 2013 in “Dermatology online journal” Different treatments for Hidradenitis suppurativa range from antibiotics and hormonal therapies to surgery, depending on severity.
6 citations
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December 2022 in “International Journal of Molecular Sciences” Hormone imbalance is linked to Hidradenitis Suppurativa, a skin condition, and treatments like anti-androgenic therapy and metformin can help. It's also suggested to check patients for insulin resistance and Polycystic Ovary Syndrome.
