FASCE: The Benefit of Spironolactone for Treating Acne in Women - Study Protocol for a Randomized Double-Blind Trial

June 2020 in “ Trials ”

Alexandra Poinas, M Lemoigne, S. Le Naour, Jean–Michel Nguyen, Solène Schirr-Bonnans, Valéry-Pierre Riche, Florence Vrignaud, L. Machet, Jean‐Paul Claudel, Marie‐Thérèse Leccia, E. Hainaut, N. Bénéton, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Anne Chiffoleau, Stéphane Corvec, Amir Khammari, Brigitte Dréno

spironolactone doxycycline acne Adult Female Acne Scoring Tool antibiotic resistance AFAST

Studysummary This study aims to conduct the first double-blind randomized trial comparing spironolactone and doxycycline for female acne treatment, with the goal of establishing spironolactone as a potentially superior alternative, especially given concerns about antibiotic resistance.

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Research cited in this study

5 / 5 results

research Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review

117 citations , February 2017 in “American Journal of Clinical Dermatology”

This systematic review concluded that the support for using spironolactone at commonly prescribed doses is based on evidence of limited quality.

research Hormonal Therapy for Acne

96 citations , September 2008 in “Seminars in Cutaneous Medicine and Surgery”

This review discusses the hormonal influences on acne's development in women and the therapeutic potential of hormonal treatments, but it reports no new clinical results.

research Acne

231 citations , April 2005 in “The New England Journal of Medicine”

This article discusses the treatment considerations for a 17-year-old boy with a six-month history of acne but reports no new research findings.

research Update and Future of Hormonal Therapy in Acne

78 citations , January 2003 in “Dermatology”

This article reviews hormonal therapy as a treatment for acne in women and suggests that emerging research on hormone synthesis and metabolism in the skin could guide future drug development.

research Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia

101 citations , January 1985 in “British Journal of Dermatology”

This article discusses oral spironolactone therapy for female patients with acne, hirsutism, or androgenic alopecia and reports no new clinical results.