Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form

    June 2008 in “ Human mutation ”
    Chunyan Mou, Helen A. Thomason, Pamela M. Willan … Denis J. Headon
    Studysummary This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
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    Research cited in this study 9

    1. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    2. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006
    3. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    4. The Hair Cycle Journal of Cell Science · 2006
    5. Edar Signaling in the Control of Hair Follicle Development ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    6. Diversity of Hair Growth Profiles International Journal of Dermatology · 2005
    7. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    8. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    9. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999