Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

    October 2015 in “ Cell reports ”
    Özlem Akilli Öztürk, Hubert Pakula, Jolanta Chmielowiec … Walter Birchmeier
    Studysummary In this study, researchers found that Gab1 is critical in controlling the hair cycle and the self-renewal of hair follicle stem cells in mice.
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    Research cited in this study 9

    1. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    2. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    3. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    4. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    5. Scratching the Surface of Skin Development Nature · 2007
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    7. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    8. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    9. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995

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    3. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006