Randomized Clinical Trial of Astaxanthin Supplement on Serum Inflammatory Markers and ER Stress-Apoptosis Gene Expression in PBMCs of Women with PCOS

This study reported that among obese women with PCOS, neither early time-restricted eating (eTRE) alone nor combined with probiotics showed significant improvements in blood pressure, inflammatory markers, oxidative stress, or antioxidant capacity compared to a standard reduced-calorie diet.

This study found that an 8-week supplementation with specific probiotic strains improved hormonal markers and oxidative stress while decreasing inflammation in women with PCOS, although clinical symptoms like acne and hirsutism showed no significant improvement compared to the placebo group.

This study found that a treatment regimen including dietary changes, oral contraceptives, fertility drugs, Glucophage or Metformin, and nutritional supplements significantly improved hormonal and immune markers and reduced clinical symptoms like ovulation and menstrual disorders in PCOS patients over three months.

The hypothesis in this study is that probiotic supplementation could improve hormonal, metabolic, inflammatory, and antioxidant markers in individuals with PCOS compared to a placebo, although results are not yet reported.

This study on women aged 18–40 with polycystic ovary syndrome reported that a three-month treatment involving dietary changes, oral contraceptives, fertility drugs, and supplements significantly improved ovulation, menstrual regularity, BMI, and reduced hirsutism, acne, and certain immune factors compared to pre-treatment and control groups.