Platelet-Rich Plasma for Hair Restoration

March 2020 in “ Facial Plastic Surgery Clinics of North America ”

Natalie Justicz, Adeeb Derakhshan, Jenny X. Chen, Linda Lee

platelet-rich plasma PRP androgenetic alopecia AGA hair restoration growth factor hair regrowth hair follicles neovascularization

Studysummary The authors concluded that platelet-rich plasma (PRP) shows promising potential as a safe treatment for hair restoration in androgenic alopecia, though further research is needed to refine its use and confirm long-term effects.

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The document from 3 years ago discussed the use of Platelet-Rich Plasma (PRP), a growth factor concentrate from a patient's own blood, for hair restoration in patients with Androgenetic Alopecia (AGA) who had not found success with other treatments. PRP was injected into areas of hair loss, stimulating hair regrowth, possibly by promoting the development of new hair follicles and neovascularization. Out of 24 studies, 21 reported positive outcomes with PRP. However, the document emphasized the need for further research to optimize PRP preparation and administration procedures, identify the most beneficial patient populations, and conduct long-term follow-up of objective hair loss outcomes.

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research Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review

23 citations , June 2018 in “Facial Plastic Surgery”

This review suggests that platelet-rich plasma is a low-risk treatment for androgenic alopecia with good patient satisfaction and positive objective outcomes, but further research is needed to refine methods and standardize outcome measurements.

research Platelet-Rich Plasma for the Aesthetic Surgeon

27 citations , July 2017 in “Facial Plastic Surgery”

This review examines the growing evidence for using platelet-rich plasma in aesthetic procedures such as hair restoration and skin rejuvenation but reports no new clinical results.

research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , February 2017 in “Dermatologic Surgery”

This study reports that plasma rich in growth factors appeared to improve hair follicle regeneration and patient satisfaction in individuals with androgenetic alopecia, though further trials are needed.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.

research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

33 citations , January 2017 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections improved hair density, quality, and thickness in males with androgenic alopecia compared to placebo, with reported high patient satisfaction and no major side effects.

The Therapeutic Response of Platelet-Rich Plasma for Androgenetic Alopecia Showed No Correlation with Growth Factors and Platelet Number

research The Therapeutic Response of Platelet-Rich Plasma for Androgenetic Alopecia Showed No Correlation with Growth Factors and Platelet Number

3 citations , December 2016 in “Blood”

This study found PRP treatment significantly increased hair count and anagen hairs in male patients with androgenetic alopecia, but there was no correlation between therapeutic response and platelet or growth factor levels.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , September 2016 in “Dermatologic Surgery”

This article proposes a mechanistic model for how platelet-rich plasma therapy may stimulate hair growth in androgenetic alopecia by promoting vascularization and activating specific signaling pathways, but it reports no new experimental results.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , September 2016 in “Dermatologic Surgery”

This study found that platelet-rich plasma did not significantly improve hair mass index or hair count in women with female androgenetic alopecia, though some patients perceived benefits in hair quality.

research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

61 citations , September 2016 in “Journal of Cosmetic and Laser Therapy”

This study found that platelet-rich plasma was not effective in treating androgenetic alopecia in men with grade 4–6 hair loss.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

This study found that platelet-rich plasma significantly increased hair density and anagen hair proportions in androgenetic alopecia patients, suggesting potential as an adjuvant therapy.

Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

This study found that adding platelet-rich plasma to microneedling improved outcomes for atrophic acne scars more than microneedling alone, according to both quantitative and qualitative assessments.

research Platelet-Rich Plasma Microneedling Versus 5% Topical Minoxidil in the Treatment of Patterned Hair Loss

13 citations , January 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

This abstract discusses platelet-rich plasma therapy for patterned hair loss but provides no new clinical results, suggesting further research is needed to determine its effectiveness.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

This study found that platelet-rich plasma injections significantly increased hair count and density in patients with male pattern hair loss without major side effects, suggesting it may be a safe and effective treatment option.

research Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

66 citations , June 2015 in “Aesthetic Plastic Surgery”

This review of 47 studies indicates that platelet preparations may significantly enhance cellular activity, wound healing, and facial aesthetic outcomes in facial plastic surgery, though potential publication bias should be considered.

research Platelet-Rich Fibrin Matrix for Androgenetic Alopecia

25 citations , May 2014 in “Facial Plastic Surgery”

In this study, intradermal injections of autologous platelet-rich fibrin matrix significantly increased hair density in patients with androgenetic alopecia at 2 and 3 months after initial treatment.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

This study reported that AA-PRP injections significantly increased hair count and density in individuals with pattern hair loss compared to baseline, demonstrating their potential for enhancing hair growth.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

In this study, PRP injections increased hair count and reduced hair loss in patients with androgenic alopecia not responding to minoxidil and finasteride, with high patient satisfaction reported.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , December 2012 in “Journal of The European Academy of Dermatology and Venereology”

This study found that interfollicular injection of autologous CD34+ cell-containing PRP preparation improved hair count and thickness in patients with pattern hair loss, with better results than placental extract treatment.

Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth