This protocol outlines a study to evaluate whether photobiomodulation, alone or with melatonin, promotes hair regrowth in dogs with Alopecia X, reporting no new results yet.
1 citations
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January 2024 in “Veterinary Dermatology” In this study, researchers cloned a two-year-old Pomeranian with Alopecia X after its accidental death and found that the cloned dog developed the same hair lesions at the same age, suggesting the condition is genetically driven rather than environmentally influenced.
December 2023 in “Veterinary dermatology” This study found that microneedling with longer needles (3 mm) showed better hair regrowth in dogs with hair cycle arrest, although most experienced recurrent hair loss during follow-up. Some dogs also developed minor, temporary itching.
3 citations
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September 2022 in “Veterinary Dermatology” This study found that 18 mg melatonin implants did not significantly prevent recurrence of canine flank alopecia compared to placebo in dogs, though the treatment was well-tolerated, with no evidence of improved efficacy.
14 citations
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January 2020 in “PloS one” In this study, using light masks to extend photoperiod was effective for maintaining the summer coat in horses and accelerating shedding in outdoor horses, but timing was crucial for success.
18 citations
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October 2017 in “PLOS ONE” This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.
10 citations
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July 2015 in “Veterinary Dermatology” This study found that noninflammatory alopecia in dogs can be caused by exposure to estradiol gel used by their owners for postmenopausal symptoms, with hair regrowth observed after minimizing exposure.
12 citations
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July 2015 in “Veterinary Dermatology” This study observed that microneedling induced significant hair regrowth and reduced hyperpigmentation in two Pomeranians with alopecia X, with stable results over 12 months.
22 citations
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September 2014 in “Veterinary Dermatology” This study found that low-level laser therapy may have promising effects on hair regrowth in dogs with noninflammatory alopecia, with most animals showing improvement after treatment.
10 citations
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July 2014 in “Veterinary dermatology” This study found that deslorelin may promote hair regrowth in intact male dogs with hair cycle arrest, but had no effect on neutered females.
10 citations
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September 2013 in “Veterinary dermatology” This study found that medroxyprogesterone injections led to partial or complete hair regrowth in some Pomeranian dogs with alopecia X, though their IGF-1 levels remained unchanged.
1 citations
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August 2011 in “Dermatology Reports” This case report describes a new family with autosomal recessive hypotrichosis simplex with woolly hair, suggesting the disorder may be underreported due to misdiagnosis.
November 2009 in “Companion Animal” The document suggests that Alopecia X in dogs is mainly a cosmetic issue and might be better left untreated.
11 citations
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January 2007 in “Veterinary dermatology” This study found that administerating 10 mg/kg intramuscular fulvestrant did not stimulate hair regrowth in Pomeranian dogs with alopecia X, though higher doses may warrant further investigation.
20 citations
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July 2006 in “Veterinary dermatology” This study found that hair regrowth in Pomeranians with hair cycle arrest treated with melatonin was not associated with a change in oestrogen receptor-α staining.
21 citations
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May 2005 in “Journal of the American Veterinary Medical Association” The exact cause of growth hormone-responsive alopecia in dogs is unclear.
40 citations
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October 2004 in “Veterinary Dermatology” In this study, trilostane treatment led to complete hair re-growth in 85% of Pomeranians and all miniature poodles with alopecia X within 4 to 8 weeks.
52 citations
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October 2004 in “Veterinary dermatology” This study found that 62% of neutered dogs with hair cycle arrest experienced partial to complete hair re-growth after melatonin treatment, but hair re-growth was not consistently linked to normal sex hormone levels.
34 citations
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March 2003 in “Veterinary Dermatology” This study found that in dogs with alopecia, certain steroid hormone levels were elevated, particularly progesterone, but not all hormone abnormalities were consistent across breeds, suggesting the need for breed-specific evaluation.