TLDR Estradiol gel can cause hair loss in dogs.
This case report described estradiol-induced alopecia in five dogs that had contact with a transdermal gel used by their owners for postmenopausal symptoms. The study aimed to raise awareness of this potential cause of noninflammatory alopecia in dogs. Skin biopsies from the affected dogs showed that most hair follicles were in kenogen or telogen phases, with mild to moderate dilation of hair follicle infundibula. Despite normal blood work and serum chemistry, one dog had elevated estradiol levels. Hair regrowth occurred after reducing or stopping exposure to the gel, indicating that estradiol gel could cause alopecia in dogs without necessarily elevating estradiol concentrations.
14 citations
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February 2015 in “Journal of the American Animal Hospital Association” Dogs exposed to their owners' hormone therapy developed hair loss, but symptoms resolved after stopping the therapy.
28 citations
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May 2012 in “Veterinary Dermatology” Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.
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New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.
10 citations
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April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
Accurate diagnosis and tailored treatments are crucial for managing hair loss in humans and animals.
1 citations
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July 2015 in “Cambridge University Press eBooks” Testosterone therapy can improve sexual function in women but long-term safety is unclear.
15 citations
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February 2013 in “Pharmaceutical nanotechnology” Finasteride delivery through skin improved using invasomes and iontophoresis.
