Iontophoretic Transdermal Delivery of Finasteride in Vesicular Invasomal Carriers

March 2013 in “ Pharmaceutical nanotechnology ”

D. Prasanthi and P. K. Lakshmi

finasteride iontophoresis transdermal delivery invasomal carriers vesicular invasomal carriers transdermal gel bioavailability Propecia

TLDR Finasteride delivery through skin improved using invasomes and iontophoresis.

The study investigated the use of invasomal carriers and iontophoresis for transdermal delivery of finasteride, a drug used for hair loss treatment. The researchers optimized the invasomal formulation and iontophoretic conditions and found that the combined effect of invasomes and iontophoresis can enhance the transdermal delivery of finasteride. In vivo studies on rabbits showed that the invasomal formulation had a higher flux and enhancement ratio compared to the control, and the transdermal gel had a higher relative bioavailability compared to the oral suspension. The study concluded that iontophoretic transdermal delivery of finasteride in vesicular invasomal carriers could be a promising alternative to oral administration.

View this study on eurekaselect.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations, July 2009 in “International Journal of Pharmaceutics”

PEVs improve minoxidil skin penetration, increasing hair growth.

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations, July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

127 citations, June 2006 in “International Journal of Pharmaceutics”

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

research Influence of Liposomes and Niosomes on the In Vitro Permeation and Skin Retention of Finasteride

3 citations, March 2005 in “Iranian Journal of Pharmaceutical Sciences”

Related Community Posts Join

6 / 1000+ results

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Only 10 more days until cassiopea releases their 12 month results for CB-03-01 our best hope of an alternative to finasteride

in Finasteride 151 upvotes 5 years ago

The conversation discusses anticipation for CB-03-01, a potential new hair loss treatment that may be more effective and have a cleaner safety profile than finasteride. Users are hopeful but cautious, discussing current treatments like minoxidil, nizoral, and dermarolling, and the possibility of combining them with CB-03-01 for better results.

community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 5 upvotes 2 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

community Alfatradiol is a topical 5AR inhibitor that this study shows is effective in stopping hair loss without sides. It can be bought OTC in Europe right now. Thoughts?

14 upvotes 8 years ago

Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

community Getting Ed from 1mg of fin not sure what to do

in Finasteride 190 upvotes 3 months ago

The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

community Topical finasteride in liposomal formulation

in Finasteride 5 upvotes 4 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

Related Research

1 / 1 results

research Iontophoretic Transdermal Delivery of Finasteride in Vesicular Invasomal Carriers

15 citations, March 2013 in “Pharmaceutical nanotechnology”

Finasteride delivery through skin improved using invasomes and iontophoresis.