Epidermal-Dermal Coupled Spheroids Are Important for Tissue Pattern Regeneration in Reconstituted Skin Explant Cultures

    November 2023 in “ npj regenerative medicine ”
    Mingxing Lei, Jingwei Jiang, Mengyue Wang … Cheng Ming Chuong
    Studysummary This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. Bioinspired Strategies for Wound Regeneration Cold Spring Harbor Perspectives in Biology · 2022
    2. Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration Cold Spring Harbor Perspectives in Biology · 2022
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    4. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    5. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    6. Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment Stem cell research & therapy · 2021
    7. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020
    8. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    9. Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences · 2019
    10. Self-Organizing Hair Peg-Like Structures From Dissociated Skin Progenitor Cells: New Insights for Human Hair Follicle Organoid Engineering and Turing Patterning in an Asymmetric Morphogenetic Field Experimental Dermatology · 2019
    11. The Influence of Interferon on Healthy and Diseased Skin Cytokine · 2018
    12. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    13. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    14. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    15. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    16. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    17. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    18. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    19. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    20. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    21. Hair Follicle Development and Hair Growth from Defined Cell Populations Grafted onto Nude Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995

    Related research 8

    1. Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration Molecules and Cells · 2023
    2. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    3. Wound-Induced Hair Follicle Neogenesis: A New Perspective on Hair Follicle Regeneration in Adult Mammals PubMed · 2020
    4. Activin A-Induced Signaling Controls Hair Follicle Neogenesis Experimental Dermatology · 2016
    5. Inducing Hair Follicle Organogenesis With Defined Environmental Protein Factors Journal of Dermatological Science · 2016
    6. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    7. Do We Need Hair Follicle Stem Cells and Hair Follicle Neogenesis to Cure Common Hair Loss Disorders? Hair transplant forum international · 2008
    8. New Hair From Healing Wounds Nature · 2007