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research Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells

8 citations , November 2020 in “Frontiers in Cell and Developmental Biology”

This study reported that exogenous R-spondin-1 can restore hair follicle neogenesis in adult mouse cells, highlighting differences in gene expression and signaling pathways between fetal and adult dermal papilla cells.

research Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures

November 2023 in “npj regenerative medicine”

This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.

Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

research Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

12 citations , September 2020 in “Stem cell research & therapy”

This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.

research Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Mechanical stimuli-induced CCL2 restores adult mouse cells to regenerate hair follicles

18 citations , March 2023 in “Molecular Therapy — Nucleic Acids”

In this study, adding CCL2 protein to organoid cultures helped adult skin cells regain the ability to self-organize and regenerate hair follicles, suggesting potential therapeutic applications.

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community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 1 year ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

community Is there any new drug that looks promising ?

26 upvotes 2 years ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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Learn

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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

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24
Trichologist
Kirsten J. Scalp
Greenville, SC, United States

Kirsten J. Scalp