Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia
April 2012
in “
Journal of Dermatological Science
”
TLDR Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.
The document from April 1, 2012, reviews the regulation of hair stem cell homeostasis by various environmental factors. It emphasizes that hair stem cell activity is influenced by both the immediate micro-environment, or stem cell niche, and broader macro-environmental factors such as adipose tissue molecules, hormones, immune and nervous system interactions, aging, circadian rhythms, and seasonal changes. The study suggests that these complex environmental networks could be targeted to develop therapies for hair growth and alopecia, potentially offering a safer alternative to direct stem cell manipulation. It also discusses specific factors like Wnt inhibitors, PDGFA, sex hormones, and the roles of the immune and nervous systems in stem cell regulation. The paper concludes that a multi-layered network of environmental factors regulates stem cell activity, and understanding this could lead to new treatments for tissue regeneration and degenerative diseases.
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15 / results
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research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells
Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.
research Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit
RANK-RANKL signaling is essential for hair growth and skin health.
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Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
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Hair follicle stem cells are controlled by their surrounding environment.
research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents
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research Hormonal regulation of hair follicles exhibits a biological paradox
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research Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells
β-catenin is essential for stem cell activation and proliferation in hair follicles.
research The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit
Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
research Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells
Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.
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research Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp
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5 / results
research Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
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