Minoxidil, Platelet-Rich Plasma (PRP), or Combined Minoxidil and PRP for Androgenetic Alopecia in Men: A Cost-Effectiveness Markov Decision Analysis of Prospective Studies

    December 2021 in “ Cureus ”
    Kevin M. Klifto, Sammy Othman, Stephen J. Kovach
    Studysummary This study found that for managing early-onset androgenetic alopecia in men, minoxidil monotherapy is cost-effective at a $50,000 willingness-to-pay threshold, while combining minoxidil with platelet-rich plasma becomes cost-effective at a $100,000 threshold.
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    Research cited in this study 17

    1. Platelet-Rich Plasma for Androgenetic Alopecia: Efficacy Differences Between Men and Women Dermatologic Therapy · 2020
    2. Comparison of Efficacy of Platelet-Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male-Type Baldness: A Randomized, Double-Blind Placebo Control Trial Indian Journal of Dermatology, Venereology and Leprology · 2019
    3. Platelet-Rich Plasma Injections in the Treatment of Male Androgenetic Alopecia: A Randomized Placebo-Controlled Crossover Study Journal of Cosmetic Dermatology · 2019
    4. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    5. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    6. Platelet-Rich Plasma and Microneedling Improve Hair Growth in Patients with Androgenetic Alopecia When Used as an Adjuvant to Minoxidil Journal of Cosmetic Dermatology · 2019
    7. A Study to Compare the Efficacy of Platelet-Rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia International Journal of Trichology · 2019
    8. Association of Hair Loss With Health Utility Measurements Before and After Hair Transplant Surgery in Men and Women JAMA Facial Plastic Surgery · 2018
    9. Bayesian Measurement-Error-Driven Hidden Markov Regression Model for Calibrating the Effect of Covariates on Multistate Outcomes: Application to Androgenetic Alopecia Statistics in Medicine · 2018
    10. Autologous Adipose-Derived Stem Cell Versus Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: Efficacy, Side Effects, and Safety Journal of clinical & experimental dermatology research · 2018
    11. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    12. Association Between Gender and Drug Cost for Over-the-Counter Minoxidil JAMA Dermatology · 2017
    13. A Comparative Study of Microneedling with Platelet-Rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia International Journal of Trichology · 2017
    14. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men Skin Pharmacology and Physiology · 2015
    15. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014
    16. Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men Journal of Dermatology · 2009
    17. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007

    Related research 5

    1. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    2. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992
    3. Treatment-Resistant Alopecia Areata: Response to Combination Therapy with Minoxidil Plus Anthralin Archives of Dermatology · 1990
    4. Alopecia Areata Treated With Topical Minoxidil Archives of Dermatology · 1984
    5. Topical Minoxidil in Alopecia Areata Journal of The American Academy of Dermatology · 1981