Clinical Efficacy of Microneedle Combined with 5% Minoxidil Solution and Finasteride in the Treatment of Androgenetic Alopecia in Males

    February 2025 in “ Archives of Dermatological Research ”
    Yan Chang, Wenxia Zhang, Jianping Zhou … Qing Zhai
    Studysummary This study found that combining microneedling with 5% Minoxidil and Finasteride significantly improved hair density and hair shaft diameter in males with androgenetic alopecia, outperforming Minoxidil alone or in combination with Finasteride, although changes in hormonal levels and trace elements were not significant.
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    Research cited in this study 25

    1. A Systematic Review of Clinical Trials Using Single or Combination Therapy of Oral or Topical Finasteride for Women in Reproductive Age and Postmenopausal Women with Hormonal and Nonhormonal Androgenetic Alopecia Advances in Clinical and Experimental Medicine · 2023
    2. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    3. Natural Products for Male Androgenetic Alopecia Dermatologic Therapy · 2022
    4. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis Skin Appendage Disorders · 2021
    5. Non-Ablative Er:YAG Laser Is an Effective Tool in the Treatment Arsenal of Androgenetic Alopecia Journal of Cosmetic Dermatology · 2021
    6. Finasteride for Hair Loss: A Review Journal of Dermatological Treatment · 2021
    7. Low-Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series Journal of The American Academy of Dermatology · 2020
    8. Microneedling: A Novel Therapeutic Approach for Androgenetic Alopecia, A Review of Literature Dermatologic Therapy · 2020
    9. Herbal Medicines for Treatment of Androgenic Alopecia PubMed · 2020
    10. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    11. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    12. Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Journal of Dermatological Treatment · 2020
    13. Microneedling Improves Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes PubMed · 2020
    14. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    15. Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
    16. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    17. Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lasers in Medical Science · 2019
    18. The Relationship Between Self-Esteem and Hair Transplantation Satisfaction in Male Androgenetic Alopecia Patients Journal of Cosmetic Dermatology · 2018
    19. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    20. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis Acta dermato-venereologica · 2018
    21. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    22. Micro-Needling Depth Penetration, Presence of Pigment Particles, and Fluorescein-Stained Platelets: Clinical Usage for Aesthetic Concerns Aesthetic Surgery Journal · 2016
    23. Microneedling Dilates the Follicular Infundibulum and Increases Transfollicular Absorption of Liposomal Sepia Melanin Clinical, Cosmetic and Investigational Dermatology · 2015
    24. Microneedle Applications in Improving Skin Appearance Experimental Dermatology · 2015
    25. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013

    Related research 9

    1. Oral Finasteride (5 mg and 2 mg) Versus Topical Minoxidil 5% in Female Pattern Hair Loss Clinical Dermatology Review · 2025
    2. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year Journal of The American Academy of Dermatology · 2021
    3. A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia Journal of clinical & experimental dermatology research · 2015
    4. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    5. Daily Finasteride Boosts Hair Growth in Men Dermatology Times E-News · 2012
    6. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    7. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    8. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    9. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994