Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study

    Chunyu Hu, Zhen Cheng, Yuanling Tao, Laixi Zhang, Yalan Zhang, Z. Chen
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    TLDR Major depression disorder increases the risk of alopecia areata, and vice versa.
    This study used a bidirectional two-sample Mendelian randomization approach to examine the causal relationships between mental disorders and non-scarring alopecia, specifically androgenetic alopecia (AGA) and alopecia areata (AA), with data from 219,469 participants for AGA and 394,872 for AA. The results showed no causal link between mental disorders and AGA. However, a significant bidirectional association was found between major depression disorder and AA, with major depression disorder increasing the risk of AA by 59% and AA slightly increasing the risk of major depression disorder by 2%. The study suggests shared genetic and immune pathways may connect depression and AA, emphasizing the need for mental health support for individuals with AA and further research with diverse populations.
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